Short and Modular Synthesis of Substituted 2-Aminopyrroles
2021
Diana-Rivero, Raquel | Halsvik, Beate | García-Tellado, Fernando | Tejedor, David | Ministerio de Ciencia, Innovación y Universidades (España) | Agencia Estatal de Investigación (España) | University of Oslo
We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, a number of 2-aminopyrroles with diverse substituents have been prepared.
Show more [+] Less [-]This research was supported by the Spanish Ministries of Science, Innovation and Universities (MICINN), Agencia Estatal de Investigación (AEI) and the European Regional Development Funds (ERDF) (PGC2018-094503-B-C21). The research stay for Beate Halsvik at IPNA-CSIC was made possible by a travel grant from the Norwegian PhD School of Pharmacy
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