Genome-wide DNA methylation dynamics during epigenetic reprogramming in the porcine germline
2021
Gómez-Redondo, Isabel | Planells, Benjamín | Cánovas, Sebastián | Ivanova, Elena | Kelsey, Gavin | Gutiérrez-Adán, Alfonso | Ministerio de Ciencia e Innovación (España) | European Commission | Gómez-Redondo, Isabel [0000-0002-9319-7580] | Planells, Benjamín [0000-0002-5910-1039] | Cánovas, Sebastián [0000-0003-4190-6258] | Kelsey, Gavin [0000-0002-9762-5634] | Gutiérrez-Adán, Alfonso [0000-0001-9893-9179] | Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
13 Pág. Departamento de Reproducción animal
Show more [+] Less [-]Prior work in mice has shown that some retrotransposed elements remain substantially methylated during DNA methylation reprogramming of germ cells. In the pig, however, information about this process is scarce. The present study was designed to examine the methylation profiles of porcine germ cells during the time course of epigenetic reprogramming.
Show more [+] Less [-]This work was funded in part by grant RTI2018-093548-BI00 from the Spanish Ministry of Science and Innovation. I. G.-R was supported by a predoctoral fellowship from the Spanish Ministry of Science and Innovation (BES-2016-077794). B.P. was supported by a Marie Sklodowska-Curie ITN European Joint Doctorate in Biology and Technology of Reproductive Health (REP-BIOTECH 675526). The funding body did not have any role in the study design, data collection, analysis and interpretation, the writing of the manuscript, or any influence on the content of the manuscript.
Show more [+] Less [-]Peer reviewed
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