Protein kinase C as a target in the control of viruses and implication for Zika virus. Cápitulo 39
2021
Blázquez, Ana B. | Saiz Calahorra, Juan Carlos | Blázquez, A. B. [0000-0002-0847-0977] | Saiz Calahorra, Juan Carlos [0000-0001-8269-5544]
7 Pág. Departamento de Biotecnología
Show more [+] Less [-]Protein kinase C (PKC) comprises a family of multifunctional lipid-dependent serine/threonine kinases that are implicated in the transduction of signals for a wide range of cellular processes, such as apoptosis, differentiation, proliferation, cellular transformation, motility, adhesion, and angiogenesis, among others. PKCs have also been involved in different steps during viral replication, and their role in virus infections has been largely analyzed, including that concerning relevant human pathogens such as Zika virus, human immunodeficiency virus, and influenza virus. In the case of Zika virus and other related flaviviruses, depending on the infecting virus, disparate results have been reported concerning the role of PKCs in their replication. In fact, PKCs are currently being investigated as a target of drug development for the treatment of viral infections and other important human disorders. Here we present a brief description of PKC structures and functions, with special emphasis on what is currently known about their role during Zika and other related flavivirus infections.
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