Diet-induced swine model with obesity/leptin resistance for the study of metabolic syndrome and type 2 diabetes
2012
Torres-Rovira, L. | Astiz, Susana | Caro, A. | López-Bote, C. | Óvilo Martín, Cristina | Pallares, P. | Pérez Solana, María Luz | Sánchez Sánchez, Raúl | González De Bulnes, Antonio
The objective of the present study was to determine the suitability of a swine breed with leptin resistance and predisposition to obesity (the Iberian pig) as model for studies on metabolic syndrome and type 2 diabetes. Thus, six Iberian sows had ad libitum access to food enriched with saturated fat (SFAD group; food consumption was estimated to be 4.5kg/animal/day) whilst four females acted as controls and were fed with 2kg/animal/day of a commercial maintenance diet. After three months of differential feeding, SFAD animals developed central obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, and elevated blood pressure; the five parameters associated with the metabolic syndrome. Thus, the current study characterizes the Iberian pig as a robust, amenable, and reliable translational model for studies on nutrition-associated diseases.
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