A systems biology approach to the evolution of plant–virus interactions
2011
Elena, Santiago F. | Carrera, Javier | Rodrigo, Guillermo
Omic approaches to the analysis of plant-virus interactions are becoming increasingly popular. These types of data, in combination with models of interaction networks, will aid in revealing not only host components that are important for the virus life cycle, but also general patterns about the way in which different viruses manipulate host regulation of gene expression for their own benefit and possible mechanisms by which viruses evade host defenses. Here, we review studies identifying host genes regulated by viruses and discuss how these genes integrate in host regulatory and interaction networks, with a particular focus on the physical properties of these networks.
Show more [+] Less [-]This work was supported by grants from the Spanish MICINN (BFU2009-06993) and Generalitat Valenciana (PROMETEO2010/019). GR is supported by a fellowship from Generalitat Valenciana (BFPI2007-160) and JC by a contract from MICINN (Grant TIN2006-12860).
Show more [+] Less [-]Peer reviewed
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