Interaction of dexamethasone and montmorillonite - Adsorption-degradation process
1989
Forteza González, M. | Galán Huertos, Emilio | Cornejo, J.
The degradation of dexamethasone in an aqueous suspension of montmorillonite seems to be the result of two apparent first order reactions. The dexamethasone content, as determined by high-pressure liquid chromatography (HPLC), rapidly decreases from 50 to 4.7 μg/ml after 24 h, and then remains almost constant during 168 h. The first stage of the decomposition is mainly consistent with an adsorption process, while the second one is characterized by a slow degradation of dexamethasone remaining in solution. X-ray diffraction (XRD) and infrared (IR) studies showed the presence of dexamethasone molecules adsorbed in the interlayer space of montmorillonite, with the basal spacing being consistent with an orientation of the plane of the rings parallel to that of the silicate sheets. Desorption studies showed a slow release of the dexamethasone from the interlayer space of montmorillonite.
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