Cloning and characterization of argC gene of Streptomyces clavuligerus
1990
Ludovice, M. | García Domínguez, M. | García Calzada, Javier | Laiz Trobajo, L. | Rubio Coque, J. J. | Martín Martín, Juan Fco. | Liras Padín, P.
Comunicación oral A 49 presentada al citado simposio, celebrado del 12-18, agosto, 1990, en Estrasburgo, Francia.
Show more [+] Less [-]S. clavuligerus is a producer of the beta-lactam antibiotic cephamycin C and the beta-lactamase inhibitor clavulanic acid. Arginine and/or ornithine are precursors of the clavulanic acid molecule and stimulate the production of clavulanic acid (Romero et al. Appl. Env. Microbiol. 52. 892. 1986). We are interested in elucidating the relationship between the arginine biosynthetic pathway and antibiotic production in S. clavuligerus.
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