Stimulation of Immunoreactivity against Endogenous Retroviruses and Protection against Leukemia of Older AKR Mice by Treatment with Antibodies against Retroviral Surface Components. Role of p 15(E) Antibody | Stimulierung der Immunreaktivität gegen endogene Retroviren und Schutz gegen Leukämie bei älteren AKR-Mäusen nach Impfung mit Antikörpern gegen Virusoberflächen-Komponenten. Rolle des Antikörpers gegen p 15(E)
1984
Schwarz, Heinz | Thiel, Heinz-Jürgen | Weinhold, Kent J. | Bolognesi, Dani P. | Schäfer, Werner
German. Antibody against viral gp71 is effective therapeutically for high leukemic AKR mice if injected immediately after birth [1]. No corresponding effect could be observed after inoculation later in life when the endogenous virus burden is already high. However, if antibody treatm ent was supplemented by the injection of p i5 (E ) antibody, a therapeutic effect was observed even in older mice first treated at an age of 2,5 months. Those m ice produced antibodies against viral surface proteins and app eared to be able to survive longer than control mice. Thus p15 (E ) antibody might be able to overcome retroviral associated immunodeficiency. This therapy may have im plications for the treatment of the apparently retroviral induced aquired immunodeficiency syndrom e (AIDS) o f man.
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Publisher Verl. d. Zeitschrift für Naturforschung; de Gruyter
ISSN 0939-5075 | 1865-7125 | 0341-0382 | 0341-0471This bibliographic record has been provided by Friedrich-Loeffler-Institut