Effects of methyltestosterone on reproduction in the Japanese quail (Coturnix coturnix japonica)
2005
Selzsam, B. | Grote, K. | Gericke, C. | Niemann, L. | Wittfoht, W. | Chahoud, I.
German. Although the hormone-mediated effects of the synthetic androgenic hormone methyltestosterone (MT) are well characterized in mammals, little is known about endocrine and other toxic effects on reproduction in birds. In a one-generation study, MT was administered to adult Japanese quail (12 pairs per group) at dietary dose levels of 0, 10, 50, and 110 ppm for a period of 3 weeks. Reproductive performance was severely affected in the groups receiving 50 and I 10 ppm MT. In females, the egg-laying rate was reduced not only related to the dose administered but also to the duration of treatment. The administration of I 10 ppm, and to a lesser extent, of 50 ppm MT resulted in an immediate and dramatic decrease in the total number of eggs laid, which complicated reliable assessment of other reproduction-related parameters. In males, the findings suggested inhibition of spermatogenesis at dose levels of 50ppm and above, resulting in a subsequent reduction in male fertility. (c) 2005 Elsevier Inc. All rights reserved
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Publisher Elsevier
ISSN 0013-9351 | 1096-0953This bibliographic record has been provided by German Federal Institute for Risk Assessment