Streptococcus suis infection on European farms is associated with an altered tonsil microbiome and resistome
2024
Fredriksen, Simen | Neila Ibáñez, Carlos María | Hennig-Pauka, Isabel | Guan, Xiaonan | Dunkelberger, Jenelle | Fernandes de Oliveira, Isabela | Ferrando, Maria Laura | Correa-Fiz, Florencia | Aragon, Virginia | Boekhorst, Jos | van Baarlen, Peter | Wells, Jerry M. | Producció Animal | Sanitat Animal
Streptococcus suis is a Gram-positive opportunistic pathogen causing systemic disease in piglets around weaning age. The factors predisposing to disease are not known. We hypothesized that the tonsillar microbiota might influence disease risk via colonization resistance and/or co-infections. We conducted a cross-sectional case–control study within outbreak farms complemented by selective longitudinal sampling and comparison with control farms without disease occurrence. We found a small but significant difference in tonsil microbiota composition between case and control piglets (n=45+45). Variants of putative commensal taxa, including Rothia nasimurium, were reduced in abundance in case piglets compared to asymptomatic controls. Case piglets had higher relative abundances of Fusobacterium gastrosuis, Bacteroides heparinolyticus and uncultured Prevotella and Alloprevotella species. Piglets developing disease post-weaning had reduced alpha diversity pre-weaning. Despite case–control pairs receiving equal antimicrobial treatment, case piglets had a higher abundance of antimicrobial resistance genes conferring resistance to antimicrobial classes used to treat S. suis. This might be an adaption of disease-associated strains to frequent antimicrobial treatment.
Show more [+] Less [-]This research was financially supported by EU Horizon 2020 Program Grant (agreement ID 727966), funded under H2020-EU.3.2.1.1. S.F. is a PhD student funded by the Netherlands Centre for One Health.
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