Evaluation of the Effects of Medetomidine and Dexmedetomidine Use on Intraocular Pressure in Cats
2023
Karslı, Birkan | Bakıcı, Merve | Pekcan, Zeynep
In the present study, it was aimed to investigate the effects of α-2 agonists used for sedation in cats, namely medetomidine hydrochloride and dexmedetomidine, on intraocular pressure. Two study groups, each containing 17 animals, were formed. One of the groups was treated with 80 µg/kg medetomidine hydrochloride, and the other group with 40 µg/kg dexmedetomidine, via IM route. The animals underwent intraocular pressure measurement before sedative agent administration (T), at the time of vomiting (T1), after vomiting (T2), at 40th minute (T3), at 60th minute (T4), and 20 minutes after atipamezol administration (T5). There was no significant difference between intra-group intraocular pressure measurements taken at different times and inter-group IOP mesaurements taken at the same time points (P>0.05). A numerical increase occurred in intraocular pressure after vomiting, and intraocular pressure was found to be lower during sedation than at the baseline. In conclusion, it was determined that the administration of medetomidine hydrochloride and dexmedetomidine via intramuscular route for sedation reduced intraocular pressure but the levels remained within reference range.
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