Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial
2017
Montoro García, Silvia | Zafrilla Rentero, María Pilar | Celdrán-de Haro, Francisco Miguel | Piñero-de Armas, Juan José | Toldrá Vilardell, Fidel | Tejada Portero, Luis | Abellán Alemán, José | European Commission | Toldrá Vilardell, Fidel [0000-0002-9843-0193]
Establishing health effects of bioactive compounds from dry-cured meat is an active area of clinical research. The present study aims to investigate whether consuming dry-cured ham with biopeptides, among other bioactive compounds, modifies blood pressure (BP) and improves other risk factors for cardiovascular disease in humans. This two-arm, cross-over, randomised controlled trial involved 38 healthy subjects with pre-hypertension. Participants received 80 g/day dry-cured pork ham or 100 g/day cooked ham (control product). A daily intake of 80 g dry-cured ham did not impair BP or 24 h sodium excretion. Total cholesterol, LDL and basal glucose levels dropped after dry-cured ham consumption (p = 0.00019, p = 0.021 and p = 0.014, respectively). Cooked ham did not affect any of the clinical and biochemical markers. Dry-cured ham components could exert a plethora of activities over the cardiovascular system including lipid and glucose metabolism. Additional studies are needed to confirm the effects of dry-cured meat biopeptides on diverse risk factors in pathological conditions.
Show more [+] Less [-]The research reported in this article was supported by the Projects BACCHUS (FP7-KBBE-2012-6-single stage, European Commission Grant Agreement 312090). SMG was supported by the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n° 608765.
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