Rift Valley fever virus: a new avenue of research on the biological functions of amyloids?
2021
Peng, Ke | Lozach, Pierre-Yves | Chinese Academy of Agricultural Sciences (CAAS) | Heidelberg University Hospital [Heidelberg] | Infections Virales et Pathologie Comparée - UMR 754 (IVPC) ; École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | CellNetworks (University Heidelberg)German Research Foundation (DFG)LO-2338/3-1INRAEIDEX-Impulsion 2020 (University of Lyon)
International audience
Show more [+] Less [-]English. Rift Valley fever is a mosquito-borne viral zoonosis that was first discovered in the Great Rift Valley, Kenya, in 1930. Rift Valley fever virus (RVFV) primarily infects domestic animals and humans, with clinical outcomes ranging from self-limiting febrile illness to acute hepatitis and encephalitis. The virus left Africa a few decades ago, and there is a risk of introduction into southern Europe and Asia. From this perspective, we introduce RVFV and focus on the capacity of its virulence factor, the nonstructural protein NSs, to form amyloid-like fibrils. Here, we discuss the implications for the NSs biological function, the ability of RVFV to evade innate immunity, and RVFV virulence and neurotoxicity.
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