Effects of Fibersol-2 and citrus powder and their incorporation into milk powder on high-fat/cholesterol-induced atherosclerosis in ApoE−/− mice
2025
Qian He | Li-Li Zhang | Jia-Ying Xu | Li Ding | Yan Liu | Haotian Feng | Jian He | Li-Qiang Qin
The present study investigated the effects of Fibersol-2 and citrus powder and their incorporation into milk powder (MP) on atherosclerosis. Male ApoE−/− mice were fed a high-fat diet (HFD) containing 1.25 % cholesterol to induce atherosclerosis. In experiment 1, model mice received HFD with Fibersol-2 or Fibersol-2 plus citrus powder. In experiment 2, model mice received HFD with MP or MP containing Fibersol-2 and citrus powder. The doses of Fibersol-2 and citrus powder used are within feasible intake levels for human and have established safety profiles. Both treatments improved lipid profile impairment, ameliorated structural injury, and inhibited atherosclerosis lesion progression in aortic sinus. Furthermore, the treatments reduced CD68 and F4/80 positive cells and reduced vascular cell adhesion molecule-1 positive cells in aortic sinus. Thus, the combination of Fibersol-2 and citrus powder improved dyslipidemia and inhibited atherosclerosis progression in the ApoE−/− mice, which was further confirmed when incorporated into milk powder.
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