Multimodal Treatment of a Peripheral Primitive Neuroectodermal Tumor Originating From the Thoracic Cavity in a Dog
2025
Leah H. Ackerman | Madison Toonder | Sarah Bosch | Varvara B. Semenova | Timothy P. Spicer | Oscar Alas | Lily S. Thorsen | Aitor Gallestegui Menoyo | Valentina B. Stevenson | Jishnu Rao Gutti | Paulo Vilar Saavedra | Rebecca Nance | Bikash Sahay | Gabriela P. Hery | Ann M. Chan | Marc E. Salute | Nesrine Benslimane | Virneliz Fernandez Vega | Rowan J. Milner
ABSTRACT Peripheral primitive neuroectodermal tumor (pPNET) is a very rare, highly malignant tumor encountered in young dogs, with only four necropsy cases in the veterinary literature. A 1.5‐year‐old male intact French Bulldog presented for evaluation of progressive left forelimb lameness and ipsilateral Horner's syndrome. Whole body computed tomography identified a 12 cm mediastinal mass with extension into the vertebral canal and multifocal metastatic lesions. Histological and immunohistochemical results were consistent with a pPNET. Chemotherapy, radiation therapy, immunotherapy, and targeted therapy were administered. Precision‐based tumor testing, including DNA sequencing and chemosensitivity assays, were performed to guide systemic treatment recommendations. A partial remission was observed 3.5 months from presentation based on imaging and improved clinical status. After 7 months of treatment, diffuse metastatic disease, including intracranial spread, was observed and the dog was euthanized.
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