Effect of dietary Acrocomia aculeata kernel oil rich in medium chain fatty acids on type 2 diabetic rats.
2020
NUNES, A. A. | BUCCINI, D. F. | JAQUES, J. A. dos S. | PORTUGAL, L. C. | GUIMARÃES, R. C. A. da | FAVARO, S. P. | CALDAS, R. de A. | CARVALHO, C. M. E. | Ângela Alves Nunes, Universidade Católica Dom Bosco; Danieli Fernanda Buccini, Universidade Catálica Dom Bosco; Jeandre Augusto dos Santos Jaques, Universidade Federal de Mato Grosso do Sul; Luciane Candeloro Portugal, Universidade Federal de Mato Grosso do Sul; Rita Cássia Avellane da Guimarães, Universidade Federal de Mato Grosso do Sul; SIMONE PALMA FAVARO, CNPAE; Ruy de Araújo Caldas, Universidade Federal de Mato Grosso do Sul; Cristiano Marcelo Espinola Carvalho, Universidade Católica Dom Bosco.
This study evaluated the effects of dietaries formulated with kernel oil of Acrocomia aculeata (AKO), rich in medium chain fatty acids (MCFA), as partial substitute of carbohydrate calories upon blood glucose, lipid profile, insulin secretion and insulin sensitivity in diabetic rats. Overall, the dietary with any AKO dose reduced hyperglycemia, ameliorated insulin secretion, lowered insulin resistance by model HOMA-IR and HOMA-Beta and augmented pancreatic beta cells functionality, restored the number of pancreatic Beta-cell in the diabetic rats and increased it in the non-diabetic rats. In addition, AKO fed rats showed reducing triglycerides, lower density lipoprotein-cholesterol and increasing high density lipoprotein-cholesterol levels, and improved hepatic function markers. Those findings suggest AKO was effective to ameliorate the health of diabetic rats.
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