ANTI-NOCICEPTIVE EFFECT OF RHIZOME OF ZINGIBER OFFICINALE(GINGER),APPLE VINGER AND THEIR COMBINATION ON ANIMAL MODELS OF PAIN IN LABORATORY RATS.
2008
Nowfel H.Jassim
This study was performed to investigate the anti-nociceptive effect of aqueous extract of Zingiber officinale rhizomes by three animal models of pain (hot plate test , tail flick and formalin test. The results showed that the oral administration of aqueous extract of ginger caused (81%) increase in hot plate time,(100%)increase in tail flick time and (41%)decrease in number of licking and biting with respect to pre-administration number. While the rats that given apple vinegar only caused (79%)increase in hot plate time, (83%)increase in tail flick time and (47%)decrease in number of licking and biting with respect to pre-administration levels. When the ginger was mixed with vinegar, it showed only (85%)increase in hot plate test,(77%)increase in tail flick test and(63%)in formalin test.
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