PROTECTIVE EFFECT OF AQUEOUS EXTRACT OF ZIZYPHUSSPINA CHRISTI FRUIT AGONIST PARACETAMOL INDUCE HEPATOAND HAEMATOTOXICITY IN ADULT MALE RABBITS
2016
Qayssar A. Obaid
Zizyphusspina-christi has a common name in Iraq "Nabka",it has been used intraditional medicine.The present study was designed to elucidate the protective effect ofaqueous extract of ziziphusspina Christi on hepato and haematotxicity induced byparacetamol in adult male rabbits. Eighteen adult male rabbits were divided randomly into 3groups of 6 rabbits each and were treated for four weeks as follows:control group, second(T1) groupreceived orally (300 mg/kg B.W.) of paracetmoldailyand third (T2) Groupreceivedorally (200 mg/kg B.W.) of crude extraction of zizyphyusspinadaily with (300 mg /kg B.W.)of paracetmoldaily. The results indicated that paracetamol administration induced hepato andhaematotoxcity manifested by significant(P<0.05) elevation in liver enzymes (AST and ALT)and reduction in total protein and albumin concentration with significant (P<0.05)decrease inRBC, Hb, PCV, MCH, MCHC and Neutrophiles whereas it increase in WBC, MCV,Lymphocyte and monocytes as a compared with control group.On the other hand, animalstreatment with aqueous extract of zizyphusspinachristiin group T2 showed a significantameliorated in biochemical andhaematologicalparameters change induce by paracetamol.Itcould be concluded that oral administration of Zizyphusextract have hepatoprotectiveand antianemicrole agonist hepato and haematotoxicity induce by paracetamol.
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