AMELIORATIVE EFFECT OF COQ10, DHEA AND THEIR COMBINATION ON EMBRYOTOXICITY AND TERATOGENICITY INDUCED BY NORFLOXACIN IN PREGNANT FEMALE RATS
2018
Bassim K. Kuoti Al-Rekabi | Mohammed A. Al-Diwan | Alaa A. Sawad
This study was designed to evaluate the ameliorating role of CoQ10 and DHEA and theircombination on norfloxacin induced maternal toxicity and fetal growth retardation in pregnantfemale rats and their fetuses. Twenty pregnant rats were divided equally into 5 groups, 4 animalsper each group as following: Control group (G1): 4 normal pregnant female received0.5ml/animal/day DMSO by using gastric gavages from 5th - 19th day of gestation. First treatedgroup (T1): 4 normal pregnant female received 400 mg/kg norfloxacin daily by gastric gavagesas a single dose. Second treated group (T2): 4 normal pregnant female received orally 400 mg/kgnorfloxacin once daily and after 1hour later injected daily with CoQ10 200 mg/kg IP. Thirdtreated group (T3): 4 normal pregnant female received orally 400 mg/kg norfloxacin once dailyand after 1hour later injected daily with DHEA 25 mg/kg IP. Fourth treated group (T4): 4 normalpregnant female received orally 400 mg/kg norfloxacin once daily and after 1hour later injecteddaily with combination of CoQ10 200 mg/kg and DHEA 25 mg/kg IP for the same period. Alldams were sacrificed at 20th day of gestation and their fetuses were collected and subjected to themorphological examinations. The obtained results showed that exposure to norfloxacin inpregnant female rats during gestational period from 5th -19th day demonstrate clearly increased inresorbed and stillbirth fetuses (dead fetuses at birth), and caused a significant decreased in fetalbody weight, fetal body length, fetal tail length, maternal weight gain and placental weight. It has been concluded that CoQ10 and DHEA prevented and treated morphological anomalies in ratfetuses. Therefore, CoQ10 and DHEA are potential therapeutic antioxidant agents againstfetotoxicity induced by oxidative stress generated by norfloxacin intoxication
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