CLINICAL AND HEMATOLOGICAL STUDIES OF CHEDIAKHIGASHI SYNDROM IN IRAQI WATER BUFFALOES (Bubalus bubalis)
2020
Hassanin H.N. AL-autaish | Saleem A. Hasso
Chediack-Higashi syndrome (CHS) is inherited autosomal recessive disorderaffected cattle and other species of animals and caused by LYST gene mutation, andcharacterized by oculocutaneous albinism, variations of total and differentialleukocyte count , different severe infections, dysfunction of platelets and a bleedingtendency.The study included 65 Iraqi water buffaloes of different ages and of bothsexes which was divided as 25 black buffaloes served as controls, 25 buffaloes withpatches or spotted animals and 15 white water buffaloes. The most important clinicalsigned showed by the animals are, white, irregular coat, unpigmented skin, hairs,eyes, with loss of appetite, emaciation, weakness, long hair than normal with tufts,anemia, photophobia with oculocutaneous depigmentation, and dullness. Animals ofboth sexes are affected specially those under one year of age. The results indicated asignificant increases (p<0.05) of body temperatures, pulse and respiratory rate ofdiseased buffalo than in controls, However a significant decrease (P<0.05) has beenregistered in erythrocytes (RBC), hemoglobin concentration (Hb), packed cell volume(PCV) and main corpuscular hemoglobin concentration (MCHC), with no statisticaldifferences was detected in mean corpuscular hemoglobin (MCH), whereas the meancorpuscular volume (MCV) was significantly increase (P<0.05). The results were also show lymphocytosis, eosinophelia and basophelia with Nutropenia andthrombocytopenia with prolonged bleeding time.Conclusion: It has been to ourknowledge that the current study is the first one in this area and the syndrome affectedthe Iraqi buffaloes and caused a clear clinical and hematological signs.
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