Effect of Tapentadol on Dogs’ Minimum Alveolar Concentration (MAC) of Isoflurane
2025
José Antonio Ibancovichi-Camarillo | Julio Raúl Chávez-Monteagudo | Marco Antonio De Paz-Campos | Lilia Gutiérrez-Olvera | Héctor Salvador Sumano-López
To evaluate the effect of oral administration of 10 mg kg<sup>−1</sup> tapentadol on dogs’ minimum alveolar concentration of isoflurane. The MAC of isoflurane was determined in seven dogs without previous medication (Group MAC<sub>ISO</sub>) and 2 h 30 min after the administration of 10 mg kg<sup>−1</sup> of tapentadol orally (Group MAC<sub>ISO+TAP</sub>). The MAC was determined by pinching the fourth finger of the pelvic limb. Data normality was analyzed using the Shapiro–Wilk test. Student’s t-test was used to evaluate the effect of tapentadol on isoflurane MAC and cardiovascular variables. The minimum alveolar concentration obtained in the Group MAC<sub>ISO</sub> was 1.52 ± 0.02%, and in the Group MAC<sub>ISO+TAP</sub>, it was 1.47 ± 0.03%, observing a significant statistical difference between groups (<i>p</i> = 0.01). The reduction in the MAC caused by administering 10 mg kg<sup>−1</sup> of Tapentadol was 3.29%. No statistically significant differences were observed when the heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were compared between groups. The oral administration of 10 mg kg<sup>−1</sup> tapentadol reduces dogs’ minimum alveolar concentration of isoflurane without alterations in the heart rate and systemic blood pressure.
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