A first step towards a consensus static in vitro model for simulating full-term infant digestion
2018
Ménard, Olivia | Bourlieu-Lacanal, Claire | de Oliveira, Samira Cássia | Dellarosa, N. | Laghi, L. | Carrière, F. | Capozzi, F. | Dupont, Didier | Deglaire, Amélie | Science et Technologie du Lait et de l'Oeuf (STLO) ; Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST | Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro) | Department of Agricultural and Food Sciences ; Alma Mater Studiorum Università di Bologna = University of Bologna (UNIBO) | Bioénergétique et Ingénierie des Protéines (BIP) ; Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) | the COST action FA1005 INFOGEST on food digestion.
In vitro alternatives to clinical trials are used for studying human food digestion. For simulating infant digestion,only a few models, lacking physiological relevance, are available. Thanks to an extensive literature review of thein vivo infant digestive conditions, a gastrointestinal static in vitro model was developed for infants born at termand aged 28 days. The model was applied to the digestion of a commercial infant formula. Kinetics of digestion,as well as the structural evolution, were compared with those obtained while submitting the same formula to theadult international consensus protocol of in vitro static digestion. The kinetics of proteolysis and lipolysis differedaccording to the physiological stage resulting mainly from the reduced level of enzymes and bile salts, as well asthe higher gastric pH in the infant model. This in vitro static model of infant digestion is of interest for scientists,food or pharmaceutical manufacturers.
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