β-lactam antibiotics, recA mutation and SOS response | β-laktamski antibiotiki, mutacija recA in odziv SOS
2015
Podlesnek, Zdravko | Podlesnek, Zdravko
English. The claim that β-lactam antibiotics induce the SOS response, allowing E. coli survival in the presence of low antibiotic concentrations, was evaluated. No association between the recA gene and antibiotic survival rate was found. Disagreements with published observations are attributed to discrepancy in minimum inhibitory concentrations and growth characteristics of various strains carrying the recA mutation. Moreover, β-lactam antibiotics do not induce expression of the SOS regulated gene cka, encoding colicin K in wild-type strains.
Show more [+] Less [-]Slovenian. Preverili smo trditev, da β-laktamski antibiotiki sprožijo odziv SOS, kar naj bi omogočalo bakteriji E.coli preživeti v prisotnosti nizkih koncentracij antibiotikov. Opravljeni poizkusi niso pokazali nobene povezave med delovanjem produkta gena recA in stopnjo preživelosti ob prisotnosti antibiotika. Neskladje z objavljenimi opazovanji lahko pripišemo razlikam v minimalni inhibitorni koncentraciji in dramatično različnim lastnostim rasti pri doslej uporabljenih sevih z mutacijo v genu recA. Z uporabo genetsko neokrnjenega seva smo ugotovili, da β-laktamski antibiotiki ne sprožijo izražanje gena za kolicin K (cka), gena, ki je nadzorovan s sistemom SOS.
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