Altilix® Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study

The objective was to evaluate the effects of 6 months of supplementation with Altilix&reg:, containing chlorogenic acid and its derivatives, and luteolin and its derivatives, on cardiovascular risk and hepatic markers in subjects with metabolic syndrome (MetS). A randomized, double-blind, placebo-controlled study was performed in 100 subjects with MetS with a follow-up period of 6 months: 50 subjects were randomized to Altilix&reg: (26 men and 24 women, mean age 63 &plusmn: 8 years) and the other 50 to placebo (28 men and 22 women, mean age 63 &plusmn: 11 years). Anthropometric, cardiometabolic, and hepatic parameters were assessed at baseline and at the end of follow-up. Carotid intima-media thickness and endothelial function were assessed by doppler ultrasound and by flow-mediated dilation of the brachial artery, respectively. The presence and degree of non-alcoholic fatty liver disease (NAFLD) was assessed by the fatty liver index (FLI), and subjects were divided into three subgroups: (1) without NAFLD: (2) with borderline NAFLD: and (3) with NAFLD. After 6 months of Altilix&reg: supplementation, we found a significant improvement vs. placebo in most of the evaluated parameters, including body weight (&minus:2.40% (95% CI &minus:3.79, &minus:1.01): p &lt: 0.001), waist circumference (&minus:2.76% (95% CI &minus:4.55, &minus:0.96): p = 0.003), HbA1c (&minus:0.95% (95% CI &minus:1.22, &minus:0.67): p &lt: 0.001), plasma lipids, FLI (&minus:21.83% (95% CI &minus:27.39, &minus:16.27): p &lt: 0.001), hepatic transaminases, flow-mediated dilation (10.56% (95% CI 5.00, 16.12): p &lt: 0.001), and carotid intima-media thickness (&minus:39.48% (95% CI &minus:47.98, &minus:30.97): p &lt: 0.001). Further, the improvement in cardiometabolic variables was independent of the degree of hepatic steatosis. Altilix&reg: supplementation improved hepatic and cardio-metabolic parameters in MetS subjects. Altilix&reg: supplementation was a beneficial approach in the management of hepatic and cardiometabolic alterations in MetS subjects.