A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects
2020
Boris Le Nevé | Adrian Martinez-De la Torre | Julien Tap | Muriel Derrien | Aurélie Cotillard | Elizabeth Barba | Marianela Mego | Adoración Nieto Ruiz | Laura Hernandez-Palet | Quentin Dornic | Jean-Michel Faurie | John Butler | Xavi Merino | Beatriz Lobo | Ferran Pinsach Batet | Anna Accarino | Marta Pozuelo | Chaysavanh Manichanh | Fernando Azpiroz
Background: Healthy plant-based diets rich in fermentable residues may induce gas-related symptoms. Our aim was to determine the potential of a fermented milk product with probiotics in improving digestive comfort with such diets. Methods: In an open design, a 3-day high-residue diet was administered to healthy subjects (n = 74 included, n = 63 completed) before and following 28 days consumption of a fermented milk product (FMP) containing Bifidobacterium animalis subsp. lactis CNCM I-2494 and lactic acid bacteria. Main outcomes: digestive sensations, number of daytime anal gas evacuations, and gas volume evacuated during 4 h after a probe meal. Results: As compared to the habitual diet, the high-residue diet induced gas-related symptoms (flatulence score 4.9 vs. 1.2: p &le: 0.0001), increased the daily number of anal gas evacuations (20.7 vs. 8.7: p <: 0.0001), and impaired digestive well-being (1.0 vs. 3.4: p <: 0.05). FMP consumption reduced flatulence sensation (by &minus:1.7 [&minus:1.9: &minus:1.6]: p <: 0.0001), reduced the number of daily evacuations (by &minus:5.8 [&minus:6.5: &minus:5.1]: p <: 0.0001), and improved digestive well-being (by +0.6 [+0.4: +0.7]: p <: 0.05). FMP consumption did not affect the gas volume evacuated after a probe meal. Conclusion: In healthy subjects, consumption of a FMP containing B. lactis CNCM I-2494 and lactic acid bacteria improves the tolerance of a flatulogenic diet by subjective and objective criteria (sensations and number of anal gas evacuations, respectively).
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