Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers
2020
Bożena Kociszewska-Najman | Natalia Mazanowska | Beata Borek-Dzięcioł | Leszek Pączek | Emilia Samborowska | Monika Szpotańska-Sikorska | Bronisława Pietrzak | Michał Dadlez | Mirosław Wielgoś
The rate of post-transplant mothers who breastfeed while on immunosuppression is progressively increasing. Data on breastfeeding while on cyclosporine-based regimens are limited. Therefore, we assessed the amount of cyclosporine and its metabolites that might be ingested by a breastfed infant by measuring the concentration of cyclosporine and its metabolites in the colostrum of seven post-transplant mothers. The mean concentration of cyclosporine in the colostrum was 22.40 ±: 9.43 mcg/L, and the estimated mean daily dose of the drug was 1049.22 ±: 397.41 ng/kg/24 h. Only three metabolites (AM1, DHCsA, and THCsA) had mean colostrum amounts comparable to or higher than cyclosporine itself, with the daily doses being 468.51 ±: 80.37, 2757.79 ±: 1926.11, and 1044.76 ±: 948.56 ng/kg/24 h, respectively. Our results indicate a low transfer of cyclosporine and its metabolites into the colostrum in the first two days postpartum and confirm the emerging change to the policy on breastfeeding among post-transplant mothers. A full assessment of the safety of immunosuppressant exposure via breastmilk will require further studies with long-term follow-ups of breastfed children.
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