Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus Talaromyces sp.: Antioxidant Activity of Two Isolated Substances
2024
Zhihao Zeng | Jian Cai | Yi Chen | Xinlong Li | Chunmei Chen | Yonghong Liu | Lalith Jayasinghe | Xuefeng Zhou
Five new metabolites, including three cyclic dipeptide derivatives (1&ndash:3) and two new polyketides (10&ndash:11), together with nine known ones (4&ndash:9 and 12&ndash:15), were isolated from the mangrove-sediments-derived fungus Talaromyces sp. SCSIO 41431. Their structures were determined using detailed NMR, MS spectroscopic analyses, and quantum chemical calculations. X-ray single-crystal diffraction analysis of 1 was described. Compounds 13&ndash:15 demonstrated activity against Staphylococcus aureus, with MIC values ranging from 25 to 50 µ:g/mL. Compound 9 showed activity against Escherichia coli, Streptococcus suis, and Erysipelothrix rhusiopathiae, with an MIC value of 100 µ:g/mL. In addition, compounds 1 and 12 showed DPPH radical scavenging activity, with the EC50 of 27.62 and 29.34 µ:g/mL, compared to the positive control (ascorbic acid, EC50, 12.74 µ:g/mL).
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