A systematic review and meta-analysis of the antihypertensive effects of camel milk hydrolysates
2024
Alhaj, Omar A. | Abodoleh, Ghaida | Abu Jadayil, Seham | Irshaid, Nagham | Mehta, Bhavbhuti M. | Faye, Bernard | Jahrami, Haitham A. | University of Petra | Kamdhenu University | Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier ; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro) | Arabian Gulf University
Source Agritrop Cirad (https://agritrop.cirad.fr/610895/)
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Show more [+] Less [-]English. This meta-analysis aimed to estimate the antihypertensive effects of camel milk (CM) hydrolysates, including the variation in camel milk hydrolysates among different hydrolysis types, incubation times, and experimental designs. The antihypertensive effect of CM hydrolysate is expressed as the percentage of angiotensin-converting enzyme (ACE) activity or IC50 value provided in μg/ml, corresponding to the 50% maximum inhibitory concentration. The greatest random effect of antihypertensive agents (IC50 μg/mL) in vitro was 122.9 at incubation time of 144–216 h. Moreover, the greatest random effect of ACE % in vitro was 76.7 after 48 h of incubation. In vivo, the random effect of ACE % was 62.7, and the incubation time was 0.16–6 h. The antihypertensive effect of CM hydrolysate depends on several factors, including hydrolysis type, incubation time, and experimental design.
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