Organophosphorus Insecticide, Methyl Parathion Toxicity in Labeo rohita
2025
P., Sivaperumal | T.V., Sankar
The effects of three sublethal concentrations of Methyl Parathion (MP) toxicity were evaluated in freshwater fish Labeo rohita. Lipid peroxidation (LPO) and antioxidant enzymes viz., superoxide dismutase (SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), glutathione peroxidase (GPx, EC 1.11.1.9), glutathione S-transferase (GST, EC 2.5.1.18) and total reduced glutathione (GSH EC 1.6.4.2) were esti- mated in liver and the neurotoxic effects were investigated by the determination of acetylcholinesterase (AChE, EC 3.1.1.7) activities in brain of Labeo rohita of size 75 ± 6 g at sub lethal exposure. The exposure to MP at 1.0 mg L-1 increased LPO by two- fold and in 45 days almost five-fold increase was observed when compared to control. SOD activity increased by three-fold (0.5 mg L-1) and six-fold (1 mg L-1) at sub lethal exposure of MP. The AChE activity decreased with increase in the concentration of MP. The results show that changes in antioxidant enzymes system and inhibition of AChE activity can be used as biomarkers of exposure to MP in aquatic ecosystems.
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