METABOLIC STATUS OF WHITE RATS IN HYPOKINESIA AND ITS PHARMACOCORRECTION OF AMINOSELETON
2019
Pavel Andreevich Parshin | Galina Anatol'evna Vostroilova | Nina Alekseevna Khokhlova | Julia Alekseevna Chaplygina
The article presents the results of studies on the effect of hypokinesia on the metabolic status of white rats. The estimation of indicators of fat, protein and carbohydrate metabolism and body weight dynamics during 45 days of modeling of hypokinesia. The experiment was carried out in a vivarium of the All-Russian Research Veterinary Institute of Pathology, Pharmacology and therapy on conventional clinically healthy sexually mature white Wistar male rats weighing 180-200 g (60 animals). For the experiment, 2 groups of animals were formed. The rats of the first group (n = 30) were kept under conditions of hypokinesia and received the drug aminoseleton by subcutaneous administration at a dose of 0.5 ml/kg body weight. Rats of the second group (control, n = 30) were kept under the same conditions, instead of aminoseleton they were injected with sterile saline. Blood sampling for biochemical studies and determination of body weight of experimental animals were carried out before the experiment (background values), then on the 5th, 15th, 25th, 35th and 45th days. Studies have shown that a decrease in motor activity has led to significant changes in protein, carbohydrate and fat metabolism.At the same time, lipolytic decomposition of fats was activated, and the content of total lipids in the blood serum increased. Experimental modeling of hypokinesia in white rats led to a decrease in the amount of total protein, an increase in urea, glucose, pyruvic acid and serum lactate dehydrogenase activity. Assessment of the dynamics of changes in rats body mass under hypokinesia showed a steady tendency to decrease. In rats that were injected with aminoseletone, all changes were less pronounced relative to those in the group without pharmacocorrection
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