Recommended application was done by spray regime for two pesticides, namely diniconazole, fenitrothion and a plant growth regulator (gibberellic acid) and their mixtures. Their residues were determined after different successive treatments in and on grape fruits in two consecutive years. The initial deposits of the fungicide diniconazole when used alone were 0.49 and 0.50 ppm for 2006 and 2007, respectively. While the initial deposits of fenitrothion reached to 11.35 and 11.19 ppm for the same interval, respectively. Initial deposits of the plant growth regulator gibberellic acid were 30.52 and 30.42 ppm for the same period, respectively. After mixing the tested pesticides and the plant growth regulator, the initial deposits loss reached 38.77 and 42.0 % for diniconazole, 43.08 and 48.16 % for fenitrothion and 6.88 and 7.00 % for gibberellic acid for the same seasons, respectively. A significant degradation was recorded with the mixture of the two tested pesticides and plant growth regulator compared with that occurred when pesticide was used alone at' the two studied seasons.