Two field experiments were conducted in 2004 and 2005 seasons at El-Bosaily farm located at Beharia Governorate, Egypt, to study the effect of three nitrogen levels 60, 120 and 180 kg/feddan applied into irrigation water "fertigation" with drip irrigation system on vegetative growth, nutrient content (N, P and K) in leaves and grain and yield of three maize (Zea mays L.) hybrids (Single Cross 10, Three Way Cross 310 and Three Way Cross 324). The experiment design was a split plot with three replications where nitrogen fertilizer levels were distributed in the main plots and maize hybrids allocated in sub plots. The obtained results indicate that the increase of nitrogen level up to 180 kg /fed significantly increased plant height, number of leaves per plant, leaf area index, grain yield and straw weight. Single Cross 10 gave the significant highest vegetative growth and grain yield comparing with the other hybrids. The high-est nitrogen level (180 kg /fed) combined with Single Cross 10 gave the significantly highest grain yield and straw weight. On the other hand, 60 kg N / fed gave the highest nitrogen use effi-ciency (NUE) value followed by 120 kg N / fed The regression analysis of nutrition content (N, P, and K %) between leaf and grain was estimated. The highest regression determination coefficient (r2) was found in nitrogen percentage with r2= 0.965 followed by potassium with r2= 0.936. The lowest r2 was found in phosphorus with r2= 0.872.