The present study was designed to investigate the effect of sweet sorghum and sugarcane syrups as antioxidants on oxidative stress biomarkers and the lipid profile i.e. serum total triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoproteins cholesterol (LDL-C)) in male rats. Cadmium was received orally to rats daily at a dose of 10mg/L in drinking water. Rats were divided into four groups,-eight rats for each- as follow: (I) control group, (II) cadmium treated group, (III) sweet sorghum syrup solution (500 ppm) once daily at a dose of 1 ml/kg body weight of cadmium acetate solution, (IV) sugarcane syrup solution (500 ppm) and cadmium acetate solution. Bioactive compounds of syrups under investigation were identified, total phenolic and flavonoid contents were determined as well. Results cleared that the effect of variation in varieties on total phenol (mg GAE/ml sample) and antioxidant activity determined by 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay of syrup was significant (P≤0.05) while it was not significant (P˃0.05) on total flavonoid (mg CE/ml sample).The highest total phenolic content was recorded by sweet sorghum syrup (1.87 mg GAE/ml sample) meanwhile, total flavonoid content varied between (1.09 and 1.36 mg CE/ml sample). Results also cleared that G.T.54-9 sugarcane and Rex sweet sorghum syrup samples exhibited significant (P≤0.05) scavenging activity compared to commercial sugarcane sample that gave lower scavenging activity (97.16, 96.07 and 74.22, respectively).Sweet sorghum and sugarcane syrups significantly affected (P≤0.05) absolute weight of organs and relative weight of both heart and kidney, while the effect on relative weight of liver was not significant (P>0.05). The treatment of sweet sorghum and sugarcane syrups during cadmium acetate administration in rats led to reduction in alanine transaminase (ALT), aspartate transaminase (AST), antioxidant enzymes, urea, creatinine and biomarkers in rat livers, like reduced glutathione , catalase ,malondialdehyde ,serum total triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoproteins cholesterol back near to normal when compared to control rats. In general, the treatment with sugarcane syrup reduced the cadmium acetate induced hepatotoxicity in rats.

Hyperuricemia (elevated serum levels of uric acid) is a key risk factor for the development of gout, and has been linked to renal dysfunction, cardiovascular diseases, hypertension, diabetes and metabolic syndrome. Hyperuricemia was induced by oxonic acid (uricase inhibitor) in experimental rats to evaluate the protective effect of alcoholic extracts from parsley shoots, celery seeds and fig leaves. The rats were divided into 6 groups, and the first one served as a normal control group. Three groups of rats were given various plant extracts (celery, parsley and fig) by oral administration using a stomach tube at a dose of 250 mg/kg. A positive control group of rats was administered orally the hypouricemic drug, allopurinol (xanthine oxidase inhibitor) at a dose of 100 mg/kg. A negative control group did not receive any plant extracts or drugs. The various plant extracts and the drug were administered for the rats every day for 9 days. On the 10th day, all groups except the normal control received a single dose of oxonic acid (250 mg/kg) by intraperitoneal injection to induce hyperuricemia. After two hours of hyperuricemia induction by oxonic acid injection, blood samples were collected from all rat groups. The protective effects of various plant extracts were monitored through measurement of uric acid and other blood biochemical analyses for the rats as well as assay of xanthine oxidase enzyme in liver tissues. The data indicated a significant (P<0.05) increase in the levels of uric acid, urea, creatinine and potassium, and a significant (P<0.05) decrease in the levels of total calcium in serum of hyperuricemic rats (negative control) compared to the normal control group. These results indicated that oxonic acid caused hyperuricemia and renal dysfunction in the nega tive control group. The protective effects of various plant extracts were established by appearance the levels of uric acid and other kidney function tests near to their normal values which appeared in the normal control group. The different plant extracts exhibited protective effects against hyperuricemia in variant efficacies compared to allopurinol. These efficacies were in the following order: fig > allopurinol > celery ≈ parsley. Comparatively, the different plant extracts exhibited inhibitory effects on the activity of liver xanthine oxidase enzyme in variant efficacies compared to allopurinol. These efficacies were in the following order: allopurinol > fig > celery ≈ parsley. It can be noticed that fig extract was the most effective treatment against hyperuricemia while allopurinol was the strongest inhibitor against xanthine oxidase activity.