In the conditions of the Republic of Belarus there was analyzed the efficiency of application of a probiotic lactic casein feed additive DKM which was developed in the Institute of Microbiology of the National Academy of Sciences of Belarus. The analyzed additive contained specially selected lactic-acid bacteria with a high bioartificial potential of metabolites. In course of the experiment there was studied the consumption of fodders (milk; oats; mixed fodders) by experimental calves; dynamics of live weight gain in the beginning and at the end of the experiment; average daily weight gain. Also, there were analyzed the background indexes of blood serum of calves, as well as the indexes of blood serum of calves in a month after application of DKM additive. Research results showed that application of the feed additive DKM promoted better palatability and use of fodders and rendered positive influence on animal productivity. Also, there was marked the normalization of metabolism that was proved y the laboratory tests of blood serum.

In the conditions of the Republic of Belarus there was determined the efficiency of application of different levels of vitamins and trace elements in feeding of servicing bulls. In course of the study there was analyzed the influence of different levels of supply of servicing bulls with vitamins A, D, E and trace elements (copper; zinc; manganese; iron; cobalt; selenium) on their reproductive ability. On the basis of the experiment there was calculated the economic efficiency of application of the developed vitamin and mineral additive. Research results showed that application of the developed protein and mineral additive in diets of servicing bulls in winter and summer periods made it possible to increase the ejaculate volume on 7,4% and 12,4% (P less than 0,05), sperm activity on 6,7 % (P less than 0,05) and 7,3% (P less than 0,01), concentration of spermium in ejaculate on 6,3% and 7,8% (P less than 0,05). Also, it promoted the lowering of percentage of defective sperm doses.

Development of new compositions of premixes for cows with milk yield of 4-5 thousands kg per lactation depending on lactation stage and pregnancy was realized in the conditions of the Republic of Belarus. Efficiency of application of premixes in comparison with the standard ones was estimated. Experiment was realized by an example of 3 groups of cows of white-and-black breed; experimental period included beginning milking period (90 days) and the main lactation period (142 days). Cows of the first control group were given premix P60-6M with combined feed. Animals of the second group were fed with premixes created on the basis of carotene and microelements content. Cows of the third group were given premixes in accordance with recommended standards. The refined standards of cow vitamin and trace elements consumption were presented. Formulas of premixes for high-producing cows were presented. The research results showed that the developed formulas corresponded to the physiological needs and their application influenced on metabolism and milk producing ability. Application of experimental premixes made it possible to increase the digestibility of nutritive substancesoin 2,3-7,5%. Application of vitamins and trace elements in heightened doses (on 10-30%) caused the increasing of their uptake and increasing of cuprum, zinc, manganese and cobalt content in blood on 11,6-40,8%

Elaboration of production technology of rape (Brassica napus) phospholipids as one of components of feed additive was realized in the conditions of the Republic of Belarus. The following equipment was used for rapeseed processing: conveyer screw for seeds, conveyer for pressed seeds (seed cake), press Farraet Zralok LC preliminary, press - Farmet Zralok PL finishing, storage-capacity for oil, storage with mixing mechanism, automatic leaf filter, compressor, air vent, air filter. Rape oil was the main product of rape processing and oil seed press cake and rape phospholipides were the additional products. Quality indexes of rape phospholipids (appearance; quantity of obtained phospholipids; moisture content; dry matter content; oil and extractive matter content; total amount of carbohydrates) were analyzed. Results of phospholipids production depending on period of filtration and pressure load in the process of oil filtration were presented. Results of rape phospholipids production depending on air pressure were given. There were obtained the following optimal parameters for phospholipids production: optimal filtration time of freshly squeezed rape oil – 5-6 hours; optimal pressure load of during the filtration of raw rape oil - 2,5-3,0 atmospheres; and optimal air pressure during the filter drying - 2,5-3,0 atmospheres. The proposed production technology of rape phospholipids made it possible to produce 4,5-5,5% of phospholipids from 1 kg of rape

Possibility of increasing of natural resistance of young livestock animals and productivity of piglets after application of experimental feed additive including dolomite powder was realized in the conditions of the Republic of Belarus. In course of study there were analyzed housing conditions of piglets; the hygienic examination of feeding rations; influence of dolomitic meal on piglet resistance and productivity. Piglets of the first (control) group were fed with standard total ration. Animals of the second and the third experimental groups were given dolomite powder in ratio of 1% and 2% of combined feed mass. Chemical content of dolomite powder, hematological indexes, disease incidence and piglet productivity were analyzed. The research results showed that in feeding rations of piglets in the analyzed swine breeding complex there was stated the deficit of calcium (14%), phosphorous (26%), magnesium (15%), cuprum (9%), zinc (27%) and manganese (27%). Research results showed that application of dolomite meal is efficient for the prophylaxis of mineral deficiency, and made it possible to increase the level natural resistance: serum bactericidal activity - on 16,4% and hemoglobin - on 19%. The optimal dolomite dose of dolomite was 2% and it promoted the lowering of disease incidence, increasing of viability and average daily weight gain

An effort to demonstrate the mechanism of homeostatic alteration of high-producing cows at the period of increasing milking capacity and peculiar features of its changing in the conditions of introduction into cattle diets of carbohydrate containing and carbohydrate compensative additives was realized in the conditions of the Republic of Belarus. In course of the experiment there were used white-and-black breed cows of 3-4 lactations with body weight of 700 kg and milk yield over the last lactation of 7000-8000 kg of milk. Experimental cows in two weeks before the supposed calving were administrated with 50 ml of propylene glycol, 6 g of niacin and 50 ml of glycerin; and in course of 60 days after calving the administration of the additives was realized in doses of 125 ml; 6 g; 50 ml, respectively. Research results showed that application of mentioned above additives rendered the positive effect on cow liver that was proved by the improved hemic function of experimental cows: increasing of quantity of erythrocytes, hemoglobin, and hematocrit

Evaluation of efficiency of chelate forms of trace elements in rations of pregnant sows as a factor of improvement of their production indices and quality of obtained litter. It was determined that introduction into pregnant sows rations of chelate forms of zinc and iron starting from the 84th day of pregnancy and till farrowing led to authentic increasing of milk yield, weight of a litter at birth and at weaning periods, to increasing of live weight of obtained litter, and also proved to be a form of hypothrophics prevention in piglets.

Determination of the influence of new premixes on sperm quality and natural resistance of sire bulls during winter and summer periods was realized in the conditions of the republic of Belarus. Application of the developed vitamin and mineral additive in rations of sire bulls in course of winter and summer periods made it possible to increase their natural resistance, that was proved by the 7,2-8,8% increasing of the bactericidal activity of blood serum indicators, 0,6% increasing of lysozymic activity of blood serum, and 3,3-5,1% increasing of the phagocytic ability of leukocytes. There was determined the possibility to increase sire bull sperm quality during different year periods by means of application of the enhanced doses of vitamins and trace elements. As a result, the ejaculate volume increased on 7,4-2,4%, concentration of male germ cells in ejaculate on - 6,3-7,8%, sperm activity - on 6,7-7,3%, and also there was stated the decrease of spoilage percent of sperm production. Results of the industrial testing have confirmed efficiency of use of the recommended vitamin and mineral additive and calculated on its basis premixes. Its application made it possible to increase the quality of bull of sperm production on 3,6-10,8%

Development of diarrheal diseases of newborn animals has a miltifactorial character and it is very difficult to optimize the structure of microbial population in alimentary tract and to carry out the correction of the microbe status only by means medical preparations. Therefore, for regulation of standard structure of intestine microflora in a complex of medical and preventive measures for diarrhea diseases of young poultry an important role is played by application of probiotics, prebiotics, and immunoamplifiers. In course of study there were used biologically active preparations produced on the basis of ecologically pure products of a natural origin: immunostimulant Alveozan, probiotics Bifidoflorin liquid and Dialakt, and prebiotics Biofon АIL and Biofon. Research was realized on one-day-old broiler chickens of Kobb-500 cross. The obtained data on the positive influence of the studied preparations on microbiocenosis of an alimentary tract of broilers chickens correlated with the indexes of natural resistance (autarcesis).The analyzed preparations made it possible to increase the local protection, stimulation of hematopoiesis (increasing of hematoglobulin, erythrocytes and leukocytes); to increase the blood content of whole protein, albumens and globulins, bactericidal activity of blood serum. Complex introduction of the analysed preparations stimulated the natural disease resistance factors, normalized the metabolic function of poultry, promoted the increasing of chicken livability and productivity

In conditions of the Republic of Belarus much attention is given to optimization of energy and protein content in diets of dry cows. Analysis of the influence of different energy and protein ratio in dry cows diets on their productivity was realized. Increasing of protein and energy balance standards of dry cows during the winter period on 10 and 15% at the expense of introduction of protein, vitamin and mineral supplements (PVMS) made it possible to increase the daily average weight gain of animals on 5,4% and 12,2%, live weight of calves at a birth on 3,6% and 8,1% and their daily average weight gain over the first month - on 3,9% and 12,1%, respectively. Feeding with PVMS produced on the basis of peas and rape made it possible to raise the digestibility of nutritive substance on 1,4-14% and accessibility of all mineral substances on 0,4-10%. The increasing of energy and protein ratio on 15% in diets of pregnant dry cows rendered the positive effect on dairy efficiency. Fodder expenses for fodder unit production decreased on 5,5 and 6,8%, respectively. Inclusion of PVMS in mixture with pea and rape flour for dry pregnant cows during the summer period made it possible to raise their live weight on 5,9% and 9,7%, weight of calves at birth on 4,2% and 7,3%, and their daily average weight gain - on 5,7 and 9,4%. Optimization of power and protein fodder of pregnant dry cows promotes the increasing of milk yields in the first 100 days of the subsequent lactation on 5,1% and 9,9% and the decreasing of forage expenses for production unit on 4,6-9,1%