Twenty-three crossbred cows with endometritis were randomized into three groups. The animals of group I and II were treated with methanol fraction of neem oil and neem seed powder (25 ml each by intra-uterine route), respectively. Whereas, the control cows (gr III) were administered with groundnut oil at similar times. Efficacy of both neem preparations was assessed by Whiteside test (color reaction to cervico-vaginal mucus) and bacterial load at subsequent estrus. The results indicate that the administration of neem preparations retrieved the cows from endometritis as majority of them showed negative to Whiteside test (100 % in gr I and 62.5% in gr II) following treatment. Reduction in bacterial load was also of higher magnitude in neem-oil (96.02±2.02%) and seed-powder fraction (98.70±0.46%) treated animals compared to controls (24.97±29.64 %). Further, a higher pregnancy rate (71.42%) was obtained in oil fraction-treated cows than seed powder fraction-treated or control cows (25% each). In this study, the therapeutic efficacy of methanol fraction of neem oil appeared superior to neem seed powder in endometritic cows.