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Effects of garlic on the cadmium accumulation in the tissue on the hematological picture in dogs.
1994
Lee B.J. | Sung E.J. | Lee M.S. | Jang I.H. | Lee H.B.
Chemopreventive effects of garlic and mugwort mixture extract on Helicobacter pylori-associated mouse gastric carcinogenesis
2014
Youm, S.Y., Chungbuk National University, Cheongju, Republic of Korea | Kim, T.W., Chungbuk National University, Cheongju, Republic of Korea | Shin, S.K., Chungbuk National University, Cheongju, Republic of Korea | Jeong, H.S., Chungbuk National University, Cheongju, Republic of Korea | Kang, J.K., Chungbuk National University, Cheongju, Republic of Korea | Kim, T.M., Chungbuk National University, Cheongju, Republic of Korea | Kim, K.H., Cosan Institute of Water Science, Seoul, Republic of Korea | Ahn, B.W., Chungbuk National University, Cheongju, Republic of Korea
Garlic and mugwort have long been used in traditional medicine to prevent various diseases. Several in vitro studies have reported protective efficacies of garlic and mugwort in cases of gastric cancer. In the present study, we investigated the cancer preventive effects of garlic and mugwort mixture extract (GME) in a Helicobacter (H.) pylori-associated gastric carcinogenesis mouse model. To induce gastric cancer, C57BL/6 mice were treated with N-methyl-N-nitrosourea and H. pylori. Various concentrations of GME (0, 100, 500, and 1,000 ppm) were then fed to the mice for 38 weeks, after which the tumor tissues were examined for histopathology, mucin histochemistry and ¥�-catenin. The incidence of gastric tumors was significantly lower in the highest dose GME-treated mice (46.7%) than control mice (85.7%) (p 0.05). The multiplicity and size of tumors were also significantly reduced by GME feeding in a dose-dependent manner (p 0.01). Furthermore, GME suppressed the H. pylori-associated chronic inflammation measured by histologic grading of H. pylori density, chronic gastritis, glandular atrophy and intestinal metaplasia in non-tumorous gastric mucosae. Our data suggest that GME suppresses gastric tumorigenesis via suppression of H. pylori-associated chronic inflammation.
Show more [+] Less [-]Therapeutic efficacy of topical formulations against dermatological disorders in dogs.
2011
Rajora, V.S., | Gupta, D.K. | Bhatt, P. | Nag, L.K.
The therapeutic efficacy of two formulations, one containing garlic and other lead carbonate and acetate, camphor, neem and eucalyptus oils were assessed in 18 and 29 clinical cases of dermatological disorders in dogs, respectively. None of the preparation showed satisfactory results against mange infestation. Both the preparations were almost equally effective in cases of fungal and non-specific dermatitis.
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