Study of sensitivity of Paenibacillus alvei to different antibiotic preparations (penicillin, tetracycline, neomycine, kanamycin, ampicillin, polymyxin, laevomycetin, enrofloxacin, tylosin, and streptomycin) was realized in the conditions of the Republic of Belarus. As the material of the research there was used the culture of agent the European foul brood caused by Paenibacillus alvei. Determination of therapeutic effectiveness of antibacterial agents in vitro conditions made it possible to choose the appropriate preparation for its use at beeyards with European foul brood caused by Paenibacillus alvei. During the experimental work there were used 10 antibacterial disks with various antibiotics. The best result against Paenibacillus alvei was shown by Tilozin, the diameter zone of growth inhibition was about 47,2+/-3,43 mm.

Sensitivity of European Faulbrut causative agent to Gentavet preparation was studied in the conditions liquid nutritive media in vitro in the Republic of Belarus. Research results showed that the studied preparation rendered the poisonous influence on European Faulbrut causative agent in concentration of 0,3 mkg/ml with the maximum rate 1:131072. The antibiotic showed the bacteriostatic ability in concentration of 0,15 mkg/ml. The antibacterial preparation did not influence the European Faulbrut causative agent in concentration of 0,01 mkg/ml. The total bacteriostatic effect the drug showed in concentration of 0,22 mkg/ml and its dilution of 1:196608.

For the well-timed prevention and treatment of sick animals there was analyzed the therapeutic efficiency of a produced survivor serum against acute respiratory diseases of sheep and lambs, as well as Catosal in combination with Nitox 200 against the mixed flow of parainfluenza-3, adenovirus, respiratory syncytial, chiamydial and pasteurellosis infection. Comparative efficiency of all mentioned preparations was presented. Research results showed the correct and timely application of drug preparations as well as their qualitative selection made it possible to lower the death cases. Application of the presented survivor serum in combination with Nitox 200 and Catosal made it possible to lower the loss of cattle in 4-5 times and increase the viability rate of animals