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Evaluation of vaccination with Neospora caninum protein for prevention of fetal loss associated with experimentally induced neosporosis in sheep
2004
Jenkins, M.C. | Tuo, W. | Dubey, J.P.
Objective--To evaluate the immunologic response of a killed tachyzoite vaccine against Neospora caninum and its effectiveness in preventing fetal loss associated with experimentally induced neosporosis in sheep. Animals--30 Dorset ewes. Procedure--Ewes were randomly allocated to receive vaccination on days 1 and 60 of the study with a killed N caninum tachyzoite preparation in a commercially available adjuvant or a saline-adjuvant mixture. A ram was placed on pasture with the ewes from days 15 to 60. Blood was collected from ewes before primary and booster vaccinations and prior to experimental challenge with N caninum tachyzoite performed on day 90; sera were assessed via Neospora agglutination (NA) and immunofluorescence antibody (IFA) assays. Blood was collected from lambs before they suckled, and sera were tested for antibodies against N caninum. Results--Of the 14 vaccinated ewes that became pregnant, 12 gave birth to live-born lambs; in contrast, 5 of 11 pregnant control ewes gave birth to live-born lambs. Whereas vaccination improved fetal survival in pregnant ewes challenged with N caninum tachyzoites, it did not appear to have any appreciable effect on transmission of N caninum to offspring, as indicated by results of NA and IFA assays. Conclusions and Clinical Relevance--The N caninum tachyzoite vaccine used in this study appeared to provide protection against fetal loss associated with experimentally induced neosporosis in a high proportion of pregnant ewes.
Show more [+] Less [-]Protective levels of canine distemper virus antibody in an urban dog population using plaque reduction neutralization test
2004
Oyedele, O.I. (Witwatersrand Univ., Johannesburg (South Africa). Anatomical Sciences School) | Oluwayelu, D.O. | Cadmus, S.I.B. | Odemuyiwa, S.O. | Adu, F.D.
Cross-sectional estimation of Babesia bovis antibody prevalence in cattle in two contrasting dairying areas in Tanzania
2004
Swai, E.S. (Veterinary Investigation Centre, Arusha (Tanzania)) | Karimuribo, E.D. | French, N.P. | Ogden, N.H. | Fitzpatrick, J. | Kambarage, D. | Bryant, M.J.
