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Chemopreventive effects of garlic and mugwort mixture extract on Helicobacter pylori-associated mouse gastric carcinogenesis
2014
Youm, S.Y., Chungbuk National University, Cheongju, Republic of Korea | Kim, T.W., Chungbuk National University, Cheongju, Republic of Korea | Shin, S.K., Chungbuk National University, Cheongju, Republic of Korea | Jeong, H.S., Chungbuk National University, Cheongju, Republic of Korea | Kang, J.K., Chungbuk National University, Cheongju, Republic of Korea | Kim, T.M., Chungbuk National University, Cheongju, Republic of Korea | Kim, K.H., Cosan Institute of Water Science, Seoul, Republic of Korea | Ahn, B.W., Chungbuk National University, Cheongju, Republic of Korea
Garlic and mugwort have long been used in traditional medicine to prevent various diseases. Several in vitro studies have reported protective efficacies of garlic and mugwort in cases of gastric cancer. In the present study, we investigated the cancer preventive effects of garlic and mugwort mixture extract (GME) in a Helicobacter (H.) pylori-associated gastric carcinogenesis mouse model. To induce gastric cancer, C57BL/6 mice were treated with N-methyl-N-nitrosourea and H. pylori. Various concentrations of GME (0, 100, 500, and 1,000 ppm) were then fed to the mice for 38 weeks, after which the tumor tissues were examined for histopathology, mucin histochemistry and ¥�-catenin. The incidence of gastric tumors was significantly lower in the highest dose GME-treated mice (46.7%) than control mice (85.7%) (p 0.05). The multiplicity and size of tumors were also significantly reduced by GME feeding in a dose-dependent manner (p 0.01). Furthermore, GME suppressed the H. pylori-associated chronic inflammation measured by histologic grading of H. pylori density, chronic gastritis, glandular atrophy and intestinal metaplasia in non-tumorous gastric mucosae. Our data suggest that GME suppresses gastric tumorigenesis via suppression of H. pylori-associated chronic inflammation.
Show more [+] Less [-]Antihepatotoxic effect of Artemisia lwayomogi methanol extract on acute hepatic injury by carbon tetrachloride in rat
1994
Kim, K.S. (Asan Institute for Life Sciences, Asan (Korea Republic). Department of Laboratory Animal Research) | Park, J.H. (Kyungpook National University, Taegu (Korea Republic). College of Veterinary Medicine)
Effect of Artemisia Iwayomogi water extract on hepatic injury by carbon tetrachloride in rats - (2) - Effect on serum ALP, LAP activities, total protein, bilirubin content and liver glycogen content
1992
Kim, K.S. (Kyungpook National University, Taegu (Korea Republic). Department of Veterinary Medicine) | Park, J.H. (Choong Ang Chemical Company, Seoul (Korea Republic))
