The effect of isoprothiolane(di-isopropyl-1,3-dithiolan-2-ylidenemalonate) aganist fat necrosis in Hanwoo(Korean Cattle) sire was evaluated. The 10 heads of Hanwoo sire suffering from fat necrosis were given 50mg/kg body weight of isoprothiolane(0.2g/kg of Fujix, Japan) orally once a day for 8weeks. In 30% of these, the size of thenecrotic fat masses had decreased significantly 7 months after the adminstration. Isoprothiolane did not affect on live body weight and semen characteristics. However the sire affected with fat necrosis had higher MCHC(Mean corpuscular hemoglobin concentration) than normal sire inhematologic values 10 weeks after administration. Number of RBC(red blood cell) and PCV(packed cell volume) 10 weeks after administration had been increased than those before administration(p0.05). The serum concentrations of creatinine, triglyceride, and total cholesterol 10 weeks after administration were higher than those before administration while the concentration of glucose was vice versa. the isoprothiolane may reduce the oxidation of glucose, increase the glucose transfer to lipids, and increase blood supply to necrotic masses. These results indicate that isoprothiolane may be useful as the therapeutic agent against fat necrosis.

With the aim to elucidate the evolution of endometrial condition after Caslick’s and Pouret’s procedures they were performed in two groups formed by 7 mares with history of subfertility and mares with pneumovagina problems that could justify by their vulvar conformation that kind of surgeries. The evaluation of endometrial condition was performed by biopsy, done just before surgery and 15 and 60 days after the postoperative period and by fertility rates evaluation in both groups. The comparison of the results of post-operative exams to the pre-operative period demonstrated histopathological modifications quite subtle not to provide changes in the endometrial classifications in both groups. Despite of it, the fertility rates observed during the experimental period allowed us to conclude that Caslick’s and Pouret’s corrective procedures provided improvement of the reproductive performance in mares with pneumovagina | Com o objetivo de avaliar a evolução da condição endometrial após as cirurgias de Caslick e Pouret, empregou-se cada uma destas técnicas em um grupo de sete éguas, com histórico de subfertilidade e portadoras de pneumovagina, que justificassem, por sua conformação vulvar, a aplicação destas cirurgias. A avaliação da condição endometrial foi feita através dos exames de biópsia do endométrio, realizados imediatamente antes da cirurgia e aos 15 e 60 dias de pós-operatório e ainda pela verificação das taxas de fertilidade em ambos os grupos, durante a estação reprodutiva do ano subseqüente. A comparação dos resultados dos exames do período pós em relação ao pré-operatório evidenciou modificações histopatológicas suficientemente sutis para não levar a mudanças na classificação endometrial durante o período de observação, porém a melhora obtida nas taxas de fertilidade nos grupos experimentais permitiram concluir que as cirurgias corretivas de Caslick e Pouret proporcionaram melhora do desempenho reprodutivo de éguas portadoras de pneumovagina.