Data on studying of efficiency of application of immunobiological preparations on efficiency and other clinical and biochemical indicators for chickens-broilers are cited. It is established, that their application to chickens-broilers promotes increase of biological value of fowl as foodstuff and is economically expedient. Application of a preparation the Biococktail-NK in an optimum dose 0,1 - 0,2 ml/goal (10,0-20,0 million microbic bodies) has allowed to increase intensity of growth of chickens-broilers by 3,5%, to lower forage expenses for production of a gain of body weight of 1 kg on 4,95%, to raise safety of young growth of birds on 3,4 % and to lower a case of birds to 1,6% (technological norm of 5%). The carried out calculations have shown, that introduction of the Biococktail-NK in a ration of broilers is economically justified, as safety of young growth in 4th trial group has raised on 3,4%, in the third - on 2,5%, in the second - on 1,3%. On the basis of the spent research fowl of the delivered samples in which ration it was entered the probiotic Biococktail-NK from calculation 0,1 - 0,2 ml/goal (10,0-20,0 million microbic bodies) since daily age within the first 5 days into 4 cycles with an interval of 7 days till the end of the cultivation period is established, that on organoleptic, physical and chemical, bacteriological indicators, and also biological value and harmlessness does not concede to meat of control group and is good-quality. In the literature there are data about influence of biologically active substances on growth and development of bird. Despite it, about influence of probiotical and immunostimulatory preparations as separately, and in a complex with probiotics, on an organism of chickens-broilers it is not enough data that induces carrying out of scientific research in the given direction. Simultaneous use of probiotics on the basis of an intestinal stick in rations of chickens-broilers is the perspective directions. Proceeding from it, working out of new effective ways of increase of chickens-broilers efficiency with a view of reception of ecologically pure and safe products of poultry farming is actual for poultry-farming economy of Belarus.

Comparative evaluation of the influence of cell-free probiotic preparation Laktimet and cellular probiotic Bifilak on productivity, livability, nonspecific response of suckling piglets in the early extrauterine life was realized in the conditions of the Republic of Belarus.Application of both probiotics increased the productivity of suckling pigs, stimulated the processes of metabolism and natural protection of organism in the early postnatal period in the conditions of specialized pig breeding complexes. Research results showed, that application of brand new cell-free probiotic Laktimet exercised higher influence on suckling pigs. Application of Laktimet made it possibler to increase piglets body weight gain on 7,8%; piglet livability - on 6,7%; and application cellular probiotic preparation Bifilak - on 5,4% and 3,3%, respectively. The same tendency was noted during the analysis of indexes of cellular factors of organism protection. Bactericidal activity of blood serum of experimental animals changed both in connection with age, and under influence of probiotic preparations. During all studied periods the bactericidal activity of blood serum was authentically (P less than 0,05) above in experimental groups in comparison with a control group. At 20-days old piglets there was stated the strengthening of bactericidal activity of blood serum. Throughout all period of experiment the superiority of trial animals over control on indicators of lysozyme activity of blood serum was observed

The effectiveness of stress prevention with use of sedative remedy Xyla in a complex with preparations Ascorbic acid with glucose, Aesel and Katosal, which improve adaptation, was researched. Application of a complex of neurotropic and adaptogenic preparations before and after dehorning promoted softening of stressful influence, that in turn has positively affected the general condition of animals and intensity of growth. Comparative test of four schemes of preventive maintenance of negative consequences of the stress caused calf dehorning, has shown their high efficiency. However more expressed stimulating influence on intensity of metabolism, antioxidant status, natural resistance, adaptation to action of stresses-factors and rates of a body weight gain were rendered by the scheme with use of preparations Aesel, Ascorbic acid with glucose and Ksila

The purpose of the research was establishment of hepatic diseases spread in cattle fattening. Trials were conducted with total number of hybrids IV-V generation of black-motley heifer with pedigree Hereford bulls. It has been established the wide spread (22,4%) of hepatic pathology. The leading place among all hepatic pathologies belongs to fatty hepatosis (13,4%) with weakly expressed symptoms, decrease of serum protein level, albumin, glucose and increase of bilirubin, globulins, hepatic enzymes and strong pathology-anatomical and histological manifestations. In the tabular form results of histologic research of liver, some biochemical indicators of blood of healthy and sick animals (M +/- m), the clinical symptoms revealed during the various periods are resulted | Целью исследований являлось изучение структуры и установление широты распространения болезней печени у крупного рогатого скота на откорме. Опыты проведены на широком поголовье помесей IV-V поколения тёлок чёрно-пёстрой породы с племенными быками герефордской породы. Установлено широкое (22,4%) распространение гепатопатий. Ведущее место среди различных форм поражения печени принадлежит жировому гепатозу - 13,4%, морфофункцинальный профиль которого определяется слабо выраженными клиническими симптомами, уменьшением уровня общего белка, альбуминов, глюкозы, повышением концентрации билирубина, активности гепатоспецифических ферментов, а также всех фракций глобулинов, яркой и характерной патологоанатомической и гистологической картиной. В табличной форме приведены результаты гистологического исследования печени, некоторые биохимические показатели крови здоровых и больных животных (M +/- m), клинические симптомы, выявленные в различные периоды

Analysis of the efficiency of application of fermented milk supplementary feed DKM (Belarus) produced on the basis of bacteria strain Lactobacilus acidophilus 55/06 in calve diets was realized in the conditions of the Republic of Belarus. Influence of feeding with acidified with the trial milk additive on forage palatability, biochemical blood structure and calve productivity was studied; economic efficiency of DKM use for processing of whole milk and its use in rations of calves was defined. Experimental batches of DKM fermented milk supplementary feed were produced at Grodno Medical Preparations Plant (Belarus). It was issued in the sterile corked polyethylene 5, 10 and 20 liter bottles or canisters. The fermented milk supplementary feed DKM could be stored at the temperature from 0 deg С up to 15 deg С. Shelf-life – 3 months from the moment of production. The additive represents the homogeneous mass of viscous consistence of cream color of various shades with a sour-milk smell. The carried out economic calculations showed, that as a result of growing capacity increase it animals of a trial group and reception of an additional total live weight gain there was stated the 6,5% decrease of expenses for fodder unit production in the experimental group. However, due to a high cost of acidified milk the cost of fodder unit in trial group was on 6,8% higher. As a result, the cost price of 1 kg weight gain in trial group (despite high additional weight gains) was stated at the level of control group. Application of fermented milk supplementary feed DKM in calve diets made it possible to lower calf disease incidence and to increase calf productivity on 11,8% without increasing the cost price of production

Studying of influence of various levels of selenium on growth, protein structure of blood serum, natural resistance, and reproductive performance of pedigree bull-calves was realized in the conditions of the Republic of Belarus. It was established, that feeding with an optimum dose of selenium (0,4 mg per 1 kg of dry matter) in rations of replacement bull-calves during the raising period promoted the increasing of daily average weight gain on 6,8%, indexes of natural resistance - on 0,5-13,9%, and sperm production quality - on 4,5-27,3%. In the conditions of optimization of selenium level of in diets the protein structure of blood serum of replacement bull-calves exceeded the similar index at control animals by the crude protein index - on 8,3 (Р less than 0,05), by albumine and alpha globulin -on 2,2% and 1,6%, respectively. Application of selenium in dose of 0,4 mg per 1 kg of dry matter made it possible to increase the indexes of natural resistance on 0,5-13,9%. Increase of selenium dose up to 0,4 mg per 1 kg of dry matter in made it possible to increase the quantity and quality of sperm of bull-calves, that was proved by the increasing of ejaculate volume on 4,5%, concentration of male germ cells in ejaculate – on 15,7% (Р less than 0,05) and male germ cells activity - on 7,3% (Р less than 0,001)

The data about influence of the developed home-produced inactivated vaccine against pasteurellosis of fur animals on blood, biochemical, immunity indicators at mink are cited. It is established, that application of the given preparation conducts to formation of the necessary immune answer. The developed domestic inactivated vaccine against pasteurellosis of fur animals is a harmless and areactogenic preparation. This vaccine does not render negative action on hematological and biochemical indicators of mink blood. They are identical to indicators in control group of fur animals. Immunization with this vaccine stimulates cellular and humoral immunity factors that testifies to formation of the proof immune answer | Приведены данные о влиянии разработанной отечественной инактивированной вакцины против пастереллеза пушных зверей на гематологические, биохимические, иммунологические показатели норок. Установлено, что применение данного препарата ведет к формированию необходимого иммунного ответа. Разработанная отечественная инактивированная вакцина против пастереллеза пушных зверей является безвредным и ареактогенным препаратом. Инактивированная вакцина против пастереллеза пушных зверей не оказывает отрицательного действия на гематологические и биохимические показатели крови норок. Они идентичны показателям в контрольной группе пушных зверей. Иммунизация инактивированной вакциной против пастереллеза пушных зверей стимулирует клеточные и гуморальные факторы иммунитета, что свидетельствует о формировании стойкого иммунного ответа

Research on studying of probiotics and prebiotics influence on natural resistance, hemogenesis, metabolism, growth, development and safety are spent on chickens of 1-37-day age in the conditions of clinic of the department of internal noncontagious diseases and the central resarch laboratory of research institute of applied veterinary medicine and biotechnology Vitebsk State Academy of Veterinary Medicine. It was established that the combined use of probiotics and prebiotics increases the defense, raises safety rate and stimulates body weight gain in broiler chickens. Hence, probiotics and prebiotics at joint application render expressed growth-promoting effect, promote high safety of young growth, disease decrease, increase in a weight gain, raise indicators of the general and local protection, stimulate hemogenesis and exchange processes during the most intense periods of bird cultivation. At separate application of probiotics and prebiotics these indicators were a little lower, but authentically above, than at chickens of control group | Исследования по изучению влияния пробиотиков и пребиотиков на естественную резистентность, гемопоэз, обмен веществ, рост, развитие и сохранность, проведены на цыплятах 1-37-дневного возраста в условиях клиники кафедры внутренних незаразных болезней и центральной научно-исследовательской лаборатории Научно-исследовательского института прикладной ветеринарной медицины и биотехнологии УО ВГАВМ. Совместное применение пробиотика и пребиотика усиливает защиту, повышает сохранность и стимулирует прирост массы тела цыплят-бройлеров. Следовательно, про пробиотики и пребиотики при совместном применении оказывают выраженное ростостимулирующее действие, способствуют высокой сохранности молодняка, снижению заболеваемости, увеличению прироста массы, повышают показатели общей и местной защиты, стимулируют гемопоэз и обменные процессы в наиболее напряженные периоды выращивания птицы. При раздельном применении пробиотиков и пребиотиков эти показатели были несколько ниже, но достоверно выше, чем у цыплят контрольной группы

Due to Herbal medicine it is possible to use cheap and ecological clean preparation. Studied medicinal forms of wormwood bitter (the wormwood bitter extract, fluid extract, Artemizitan) in therapeutic dose stimulate the factors of natural resistance beside animals. Results of studying of lysozyme activity in blood serum have shown that preparations of wormwood bitter have caused authentic increase of this indicator in comparison with control animals, both in pigs, and at sheep. Bactericidal activity of blood serum was authentically more than in control group, both at pigs, and at sheep after introduction of infusion of wormwood bitter. Studying of influence of wormwood bitter on phagocytosis indicators has shown, that all medicinal forms of plant have made stimulating impact on phagocytal activity of neutrophils and phagocytal number both in experiences on pigs, and on sheep. Artemitizan has caused authentic increase and phagocytal index. Thus, the research will be coordinated with literary data, that preparations of wormwood bitter make stimulating impact on indicators of natural resistance of animal blood | Благодаря фитотерапии возможно использование дешевых и экологически чистых препаратов. Изученные лекарственные формы полыни горькой (настой полыни горькой, жидкий экстракт полыни горькой, артемизитан) в терапевтических дозах стимулируют показатели естественной резистентности у животных. Результаты изучения лизоцимной активности в сыворотке крови показали, что препараты полыни горькой вызвали достоверное повышение этого показателя по сравнению с контрольными животными, как у свиней, так и у овец. Бактерицидная активность сыворотки крови была достоверно больше, чем в контрольной группе, как у свиней, так и у овец после введения настоя полыни горькой. Изучение влияния полыни горькой на показатели фагоцитоза показало, что все лекарственные формы растения оказали стимулирующее влияние на фагоцитарную активность нейтрофилов и фагоцитарное число как в опытах на свиньях, так и на овцах. Артемизитан вызвал достоверное повышение и фагоцитарного индекса. Таким образом, наши исследования согласуются с литературными данными, что препараты полыни горькой оказывают стимулирующее влияние на показатели естественной резистентности крови животных

There was developed a method of increasing the efficiency of used feeds and poultry productivity by means of stimulations of natural resistance of an organism by biologically active substances (Vigozin preparation, containing carnitine). Application of preparation Vigozin with potable water twice in a dose of 1 ml on 1 l of water within first 3 days and for 13th day of cultivation allows to raise safety of chickens-broilers on 2,3% at the expense of normalization of metabolism at young growth and preservation of a functional condition of a liver. Results of the general clinical and the immunological analysis of blood at chickens-broilers of control and trial groups (M+/-m, n=10), biochemical indicators of blood at chickens-broilers of control and trial groups in age dynamics (M+/-m, n=10) are presented. | Целью работы являлось научное обоснование и разработка способа повышения эффективности использования кормов и продуктивности птицы путем стимуляции естественной резистентности организма биологически активными веществами (препарат Вигозин, содержащий карнитин). Применение препарата Вигозин с питьевой водой двукратно в дозе 1 мл на 1 л воды в течение первых 3-х суток и на 13-й день выращивания позволяет повысить сохранность цыплят-бройлеров на 2,3% за счет нормализации обмена веществ у молодняка и сохранения функционального состояния печени. Представлены результаты общего клинического и иммунологического анализа крови у цыплят-бройлеров контрольной и опытной групп (M+/-m, n=10), биохимические показатели крови у цыплят-бройлеров контрольной и опытной групп в возрастной динамике (M +/- m, n=10).