In the conditions of the Republic of Belarus there were studied circadian rhythms of some haemotological and biochemical blood indexes of clinically healthy calves and calves with a respiratory syndrome. There was analyzed the efficiency of administration a new complex mineral preparation CMP for correction of internal desynchronoses in complex therapy of calves with respiratory pathologies. Diseases of calves with a respiratory syndrome were accompanied by infringements of circadian fluctuations rhythm (internal desynchronosis) of haemotological and biochemical blood indexes. Application of an antimicrobial preparation Ampicillin for treatment of respiratory diseases of calves promoted the recovery of calves. Introduction of CМP preparation into therapeutic regimen of calves with respiratory syndrome proved to be rather effective; it promoted the correction of metabolic desynchronoses which accompanied the basic disease. Combined application of CМP and Ampicillin made it possible to speed up the clinical recovery of calves and on 30% to prevent animal mortality.

Determination of possible relations between some metabolic activity indexes of Large White pregnant sows (with various pregnancy stages) and their offspring was realized in the conditions of the Republic of Belarus. In the experimental animals there was taken blood for hematologic and biochemical tests. In peripheral blood there was analyzed the average content of hemoglobin, total number of erythrocytes, leukocytes, thrombocytes and corpuscular volume. Content of total protein, albuminolesterin, concentration total kalium and nonorganic phosphorus, magnesium, iron, zinc, activity of alanine- and aspartate transaminase were evaluated in blood serum. Blood tests were made on 84th day of pregnancy, in 30 days before farrowing, on the 2-nd lactation day and on the 2-nd and 35-th days of piglet life. Research results showed high degree of persistence of iron and zinc deficiency of pregnant sows in the conditions of modern national swine production. The obtained results proved the presence of close relationship between metabolic processes of sows and piglets that was revealed in low degree of stores supply with elements which had been in deficit for their mothers

Studying of therapeutic effectiveness of metabolic probiotic Diamixan (sterile concentrate of waste products of Lactobacillus acidophilus, Lactobacillus debrueckii, and Streptococcus salivarius) against piglet gastroenteritis appearing at weaning period was realized in the conditions of the Republic of Belarus. The analyzed preparation contained complex of substances: bioartificial lactic acid, amino acids, polysaccharides, and some other ingdredients. In course of analysis of the state of intestinal microbiocenosis there were analyzed the following indexes: bifidus bacteria; lactic acid bacillus; E. coli; enterococcus; Proteus; Staphylococcus saprophyticus; Clostridia; yeast-like fungi; enterobacteria. Research results showed that application of the examined preparation made it possible to shorter the terms of animal recovery on 2,2 days, as well as to facilitate the severity of a disease. Bottle feeding of the metabolic probiotic promoted the stabilization and normalization of the main hematological indexes. The analyzed preparation created the optimal pH in lumen of the intestine, inhibited the rowth of opportunistic pathogenic bacteria, promoted quicker reconstruction of microecological status by means of normalization of standard flora of bifidus bacteria and lactic acid bacillus

Determination of a degree and stages of metabolic disorders of aborted sows and sows which gave birth to dead fetus was realized in the conditions of the Republic of Belarus. Analysis of biochemical profile of blood of experimental sows was given. Typical deviations of biochemical status indexes in the conditions of reproduction pathology were determined. The highest degree of deviations of biochemical blood profile (indexes of fat, protein and mineral metabolism) was stated at aborted sows. At sows which gave birth to dead fetus there were stated abnormalties functional state of kidneys and liver, indexes of carbohydrate and mineral metabolism.

Analysis of national studies and literary sources on problems of haemophilus pleuropneumoniae of swine was realized in the conditions of the republic of Belarus. Research was realized in the conditions of Agricultural Production Co-operative Uritskoe (Gomel region, Belarus). It was established that medical actions gave positive result only at early stages of disease.

Belarus concerns a biogeochemical province with the lowered content in environment of such microelements, as iodine, selenium, copper, cobalt, manganese, zinc and some other. It conducts to infringement of intensity and an orientation of processes of an exchange of proteins, carbohydrates, lipids, and finally - to decrease in their growth and development of an organism of young growth. High cost of foreign preparations for treatment and preventive maintenance of an alimentary anaemia, low bioavailability of iron and toxicity do not provide purposeful disesase control and immunodeficiencies arising on its background. The special urgency is got by research of means of complex preventive maintenance of an alimentary anaemia and immunodeficiencies. It has been established that the recipes N1-3 have proved to be non-toxic for laboratory animals and have no effect on the meat quality.

In the conditions of the Republic of Belarus there was realized the determination of efficiency of application of saline and chelate forms of copper and cobalt for treatment of anemic syndrome of cattle. It was found out that lack of copper and cobalt in cattle diets in the conditions of normal supply of iron could be a cause of cattle anemic syndrome. It took place because of the iron adsorption disorder in intestines and its inclusions in haem, as well as lowering of ehritropoztin synthesis. In the conditions of administration of copper and cobalt-containing preparations for animals there was noted the increasing of iron and haemoglobin content in blood. Administration of ethylene diamine tetraacetates of cobalt and copper made it possible to reduce considerably all evidences of clinical and laboratory symptoms of anemia and hypomicroelementosis in comparison with application of copper sulphate and cobalt.

In the conditions of the Republic of Belarus clinic and production conditions there was analyzed the prophylactic and therapeutic efficacy of a new national complex iron dextrane preparation Ferovital against deficiency (nutritional) anemia of new-born cattle and swine. In course of the study there were analyzed results of hematological and biochemical tests of blood of piglets which were administrated with Ferovital preparation. There were also marked the general economic index: live weight gain, disease incidence, piglet death rate, etc. Research results showed that the Ferovital preparation had an expressed prophylactic and therapeutic efficacy both in clinic and production conditions.

Searching for new, effective and safe methods of treatment of hookworm disease (ancylostomatidosis) of dogs caused by Ancylostoma caninum and Uncinaria stenocephala was realized in the conditions of the Republic of Belarus on the basis of studying of spices composition and dissemination of Ankilostomatidae, age-specific and seasonal disease dynamics, testing of medical and preventive preparations Univerm and Fenbendazol. In the Republic of Belarus Ancylostoma caninum was stated 4,2% of studied cases and Uncinaria stenocephala – in 14,3%. The maximum intensity of the invasion was stated in summer and autumn periods: in cases of individual keeping – 19,4%; in cases of group keeping the disease transformed into enzootic form with 66,7% affect. In winter period there was the lowest invasion – up to 1,4%. The preparation Univerm administrated twofold with feed in dose of 0,1 mg/kg with 24 hours interval proved to be highly effective therapeutic agent with extensefficiency100%. Anthelmintic Fenbendazol administrated once with feed in dose of 0,005 g/kg proved to be highly effective with extensefficiency 80% and intensefficiency 98,84%. Hematological indexes of sick dogs showed the evidence of erythropenia (4,30-4,80 x 10E12/l), hemoglobinemia (113-119 g/l) and eosinophilia (up to 11%), as well as the increased quantity of leukocytes on 5,46% - 23,61 %, and the lowered quantity of lymphocytes on 15,84 % in comparison with healthy animals indexes

Realized in the conditions of the Republic of Belarus experimental infestation of American mink with monoinvasion of Strongyloides martis and parasitocoenoses of Strongyloides martis and Eimeria vison caused significant changes of hematological blood indices. Associations of the nematodes and coccids caused more intensive changes of blood morphological composition in comparison with monoinfection. The level of hemoglobin and erythrocytes at monoinvasion decreased on 18,8 % (р less than 0.05) and 23,3 % (р less than 0.05); in the conditions of an associative form - on 19,1 % (р less than 0.05)) and 31,4%, respectively; at the same time the quantity of leukocytes increased at monoinvasion on 41,3 % (р less than 0.05)), at the associative form - on 54,2 % (р less than 0.05)). In leucogram there were stated an eosonophilia and netrofilia.