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Evaluation of antitumor, hepatoprotective and antimutagenic potentials of Phellinus gilvus
2008
Kang, E.H. (Kyungpook National University, Daegu, Republic of Korea) | Kim, K.S. (Kyungpook National University, Daegu, Republic of Korea) | Park, S.C. (Kyungpook National University, Daegu, Republic of Korea), E-mail: parksch@knu.ac.kr
This study was carried out to evaluate the antitumor, hepatoprotective and antimutagenic activities on hot water extract of Phellinus gilvus (PGE). Growth of tumor in mice that were orally given 0.25, 0.5, 1.0, 2.0 gㆍkg-¹ dose of PGE was inhibited in a dose-dependant manner (p less than 0.05). The hepatoprotective effect of PGE in the carbon tetrachloride (CCl₄)-intoxicated rats was studied. In CCl₄+PGE groups, PGE was orally administered with 100 mg/kg/day dose 7 days before the treatment of CCl₄. The serum activity of aspartate aminotransferase and alanine aminotransferase in CCl₄+PGE group were decreased at a rate of 59.6% and 54.1% compared with those in CCl₄ group, respectively (p less than 0.05). Also, total cholesterol and triglyceride in CCl₄+PGE group were significantly decreased at a rate of 90% and 73.6% compared with those in CCl₄ group (p less than 0.05). In the Ames test, we confirmed PGE doesn't have any activity as a mutant, and PGE showed inhibitory effect against mutagenesis induced by 2-amino fluride and sodium azide in Salmonella typhimurium TA98, TA100 and TA 1535 in a dose-dependent manner. From the above results, we may suggest that PGE might have useful as a material for functional food and/or animal pharmaceutics.
Show more [+] Less [-]Protective effects of EDTA and EGTA against CCl₄-induced acute hepatotoxicity in mice
2007
Park, S.G. (Kangwon National University, Chuncheon, Republic of Korea) | Cho, Y.D. (Kangwon National University, Chuncheon, Republic of Korea) | Shin, T.K. (Cheju National University, Jeju, Republic of Korea) | Wie, M.B. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: mbwie@kangwon.ac.kr
This study investigated the protective effects of ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA), an extracellular calcium chelator, and ethylenediaminetetraacetic acid (EDTA), which chelates calcium and most metal ions, against carbon tetrachloride (CCl₄)-induced acute hepatotoxicity in mice. Mice were treated with EGTA or EDTA at a dose of 20 (low) or 100 mg/kg (high) subcutaneously 1 h before CCl₄ administration. The mice were fasted and sacrificed 18 h after CCl₄ treatment.
Show more [+] Less [-]Antihepatotoxic effect of Artemisia lwayomogi methanol extract on acute hepatic injury by carbon tetrachloride in rat
1994
Kim, K.S. (Asan Institute for Life Sciences, Asan (Korea Republic). Department of Laboratory Animal Research) | Park, J.H. (Kyungpook National University, Taegu (Korea Republic). College of Veterinary Medicine)
Effect of Artemisia Iwayomogi water extract on hepatic injury by carbon tetrachloride in rats - (2) - Effect on serum ALP, LAP activities, total protein, bilirubin content and liver glycogen content
1992
Kim, K.S. (Kyungpook National University, Taegu (Korea Republic). Department of Veterinary Medicine) | Park, J.H. (Choong Ang Chemical Company, Seoul (Korea Republic))
