In the conditions of the Republic of Belarus there was studied a state of lipid peroxidation, antioxidant protection and activity of hepatospecific enzymes of blood plasma of piglets. Research results showed that weanling piglets which had low body weight in the conditions of industrial breeding technology were characterized by high intensity of processes of lipid peroxidation. At the same time, the antioxidant system reacted adequately to the mentioned above changes. There was noted a high dependence between the content of Schiff's bases which were the end-products of lipid peroxidation processes, and the activity display of amplifier hepatospecific enzymes of blood plasma of weanling piglets. The received results of research can be used for estimation of a condition of prooxidant and antioxidant status, and in a complex with data on activity of sorbitol dehydrogenases, isocitratdehydrogenases and glutamatedehydrogenases - for an estimation of a functional state of a liver of weanling piglets with low body weight at an initial stage of their breeding.

In the conditions of the Republic of Belarus there was realized a comparative study of peculiar features of influence of combined application of Khelavit preparation and protein-vitamin-mineral feed supplements Khendriks and Spaeta-kontsentrat on health status of cows and quality of obtained cow milk after application of these preparation for the preventive treatment of osteodystrophy. In course of study there were analyzed haematologic and biochemical blood indexes of cows after application of the experimental preparations. Results of physical and chemical indexes of milk were presented. Research results showed that the analyzed protein, vitamin and mineral feed supplements caused the normalization of biochemical blood indexes in comparison with animal of a control group. Besides, application of mentioned above drugs promoted the increasing of veterinary and sanitary quality and technological properties of produced milk.

In the conditions of the Republic of Belarus there was determined the influence of different rates of lithium addition into mixed fodders for sows feeding on hematological indexes and their reproductive qualities. In course of the study there was analyzed the dynamics of body weight of sows over the reproductive period; indexes of productivity of sows (number of born piglets; weight of 1 piglet; litter weight; weight of weanling piglets; number of weanling piglets; etc.); hematological indexes of sows; state of humoral factors of immunity of sows. Research results showed that in case of lithium application in diets of sows there was stated an improvement of hematological indexes and immunity functions and resistance. The optimal level of lithium in rations was 15 milligram per 1 kilogram of dry matter of a diet. This dose essentially promoted the increasing of reproductive performance, piglets weight and milking capacity of sows as well as better viability of piglets.

In the conditions of the Republic of Belarus there was analyzed the efficiency of application of a probiotic lactic casein feed additive DKM which was developed in the Institute of Microbiology of the National Academy of Sciences of Belarus. The analyzed additive contained specially selected lactic-acid bacteria with a high bioartificial potential of metabolites. In course of the experiment there was studied the consumption of fodders (milk; oats; mixed fodders) by experimental calves; dynamics of live weight gain in the beginning and at the end of the experiment; average daily weight gain. Also, there were analyzed the background indexes of blood serum of calves, as well as the indexes of blood serum of calves in a month after application of DKM additive. Research results showed that application of the feed additive DKM promoted better palatability and use of fodders and rendered positive influence on animal productivity. Also, there was marked the normalization of metabolism that was proved y the laboratory tests of blood serum.

Evaluation of a quantity and phagocyte activity of leucocytes, immunoglobulins, T- and B-lymphocytes in blood serum of sheep in the process of stimulation of central nervous system with caffeine sodiobenzoate for the increasing of nonspecific animal resistance was realized in the conditions of the Republic of Belarus. Romanov yeld ewes were divided into two groups. Experimental sheep were entered caffeine sodiobenzoate intramuscularly in dose 0,012 g/kg of live weight twice a day with 6 hours interval. Controlled group of sheep were entered physiological salt solution in accordance with the same scheme. Blood samples were taken before preparation entering and after 1, 3, 6, 12 and 24 hours of test beginning. Immunoglobulin concentration in blood serum was estimated by electrophoresis method in polyacrylamide gel. Quantity of T- and B- lymphocytes was estimated by active rosette test. Phagocyte activity of leucocytes was estimated with application of germ culture St. albus. Leucocytes number was accounted in Gorjaev's chamber. Research results showed that under conditions of central nervous system stimulation by caffeine sodiobenzoate there was stated the increasing of nonspecific resistance. It was proved by the increasing of the total number and phagocytic activity of leukocytes, immunoglobulins (IgG, IgA and IgM), T- and B- lymphocytes

Investigation of dynamics of indexes of carbohydrate and lipid exchange at piglets with various body weight at after weaning period, determination of possibility of their application as energy deficit markers, as well as studying the influence of vitamin and energy additive based on rapeseed oil on the indexes of carbohydrate lipid exchange in blood of piglets and their economic indexes were realized in the conditions of the Republic of Belarus. Research results showed that at the weaning period and after it there were changes in piglet organisms caused by adaptation to new housing conditions and that subsequently led to transformation of energy metabolism. After the weaning period there was stated increasing of level of lipid exchange in the energy supply of adaptation process, that was proved by the increased level of total lipids and triglycerides. Low indexes of carbohydrate and lipid exchange of the group piglets with low growth indicated to the insufficient level of energy supplying, needed for growth and adaptation. The studied vitamin and energy additives based on rapeseed oil corrected the level of carbohydrate and lipid exchange and could be used as a prophylactic agent against energy deficiency conditions of weaning piglets

Investigation of connection of experimental trichophytosis and relations between changes of clinical implications of disease and dimensions of some immunological indexes was realized in the conditions of the Republic of Belarus. At the first stage of the experiment there analyzed 48 guinea pigs (Cavia porcellus) infected with Trichopyton verrucosum. Phagocytic ability of phagocytes and level of circulating antibodies in indirect hemagglutination test were investigated each 5 days before and during disease. The second stage was realized by the example of 2,5-6 months old calves. In course of study there were analyzed blood and blood serum indexes, indexes of nonspecific resistance, as well as some indexes of cell-mediated immune response and antibody mediated immunity. Comparative analysis the following morphological and biochemical blood indexes of clinically healthy calves, calves after trichophytosis, and calves sick with mild, moderate and severe of disease were presented: erythrocytes; hemoglobin; leukocytes; basophils; eosinophiles; rods; microxyphils; lymphocytes; monocytes; ESR; total albumin; albumins; alpha globulins; beta globulins; gamma globulins; carotene; calcium; inorganic phosphorous; alkaline reserve; copper. The realized experiment made it possible to conclude that determination intensity of leukocyte absorption of microconidia of the agent, antibodies against the agent, and specific for cytoplasm fungus, morphological and biochemical blood indexes made it possible to control the development of inflammatory phenomenon in centers of infection, as well as to predict the formation of face, infiltrative and suppurant disease forms

In the conditions of the Republic of Belarus there was realized a study of age-specific features of level of erythrocytes, haemoglobin in blood, activity of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase, as well as concentration of calcium, phosphorous, magnesium and ferrum in blood serum of suckling colts in the first 6 months of life. In the studied animals there was stated increased levels, haemoglobin and ferrum concentration in blood, but during the 6th month of life the same indexes decreased considerably. The most considerable changes оf blood serum enzymatic activities occurred at the age of 2 and 6 months. Thus, during the 2nd month of life a raise in ALAT, LDH activity, calcium and phosphorus concentration was noticed. At the age of 6 months ALAT and ASAT levels increased, and LDH activity, magnesium and phosphorus concentration decreased. During the first 6 months of life the ALP activity was on a high level and underwent no reliable changes. As the research showed, blood serum enzymatic activity and concentration of calcium, phosphorus, magnesium and ferrum depended on colt age and change at the process of growth and development of animals.

Realized in the conditions of the Republic of Belarus experimental infestation of American mink with monoinvasion of Strongyloides martis and parasitocoenoses of Strongyloides martis and Eimeria vison caused significant changes of hematological blood indices. Associations of the nematodes and coccids caused more intensive changes of blood morphological composition in comparison with monoinfection. The level of hemoglobin and erythrocytes at monoinvasion decreased on 18,8 % (р less than 0.05) and 23,3 % (р less than 0.05); in the conditions of an associative form - on 19,1 % (р less than 0.05)) and 31,4%, respectively; at the same time the quantity of leukocytes increased at monoinvasion on 41,3 % (р less than 0.05)), at the associative form - on 54,2 % (р less than 0.05)). In leucogram there were stated an eosonophilia and netrofilia.

Creation of a composition for disinfection of livestock houses which possessed an expressed sanitizing action and was safe for livestock animals after the repeated application was realized in the conditions of the Republic of Belarus. Formula of the presented the following components: potassium persulphate, amber and citric acids, sodium dodecyl sulfate. For strengthening of disinfecting effect there was also used detergent – sodium dodecyl sulfate (lauryl). Rational balance of components was selected and bactericidal properties of the preparation were estimated at the first stage of the study. At the second stage there was estimated theinfluence of the composition on livestock animals after the repeated aerosol spraying at their presence, as well as the biochemical, morphological and immunological blood indexes of experimental animals. Toxicity of the composition was realized by an example on white mice and rabbits. Research results showed that the composition for disinfection created on the basis of potassium persulphate and organic acids in the presented concentrations rendered the expressed bactericidal action, did not influence on metabolic indexes, had not skin and skin-resorptive action and could be used for air disinfection and surface areas of livestock houses in animal presence