Definition of quality parameters and chemical composition of feeds, evaluation their nutritional value and composing on this basis optimal rations for high productive animals are the most significant conditions for their health and production. More often metabolism disorders registers in the conditions of intensive animal production, at high dairy efficiency and intensive fattening. At animals at disorder of key parameters of technology (unbalanced feeding, hypodynamia, lack of insolation) is broken metabolism, decreases natural resistance, goes down quality of production that conducts to disease, premature culling and to the compelled slaughter of animals. On frequency these diseases occupy on the average 10% from all noncontagious diseases, and on dairy complexes with industrial technology and in specialized feeding economy at intensive cultivation on their share it is necessary over 30% of a noncontagious pathology. Today the control of rations on such indicators, as dry matter level, quantity of exchange energy, the maintenance of a crude and digested protein, amino acids, sugars, starch, cellulose, fat, macro-and microelements, vitamins, and also sugar-energy-protein and calcium-phosphoric parities, acid-base balance has got special value. The lack of those or other nutrients causes infringement of a clinical condition of animals and reduces their efficiency. Among the most widespread diseases of the animals registered in animal industry: cattle ketosis, osteodystrophy, endemic struma, hypomagnesiemia tetany, pasturable tetany, microelementosis, hypovitaminoses A and Е.

Comparative evaluation of the influence of cell-free probiotic preparation Laktimet and cellular probiotic Bifilak on productivity, livability, nonspecific response of suckling piglets in the early extrauterine life was realized in the conditions of the Republic of Belarus.Application of both probiotics increased the productivity of suckling pigs, stimulated the processes of metabolism and natural protection of organism in the early postnatal period in the conditions of specialized pig breeding complexes. Research results showed, that application of brand new cell-free probiotic Laktimet exercised higher influence on suckling pigs. Application of Laktimet made it possibler to increase piglets body weight gain on 7,8%; piglet livability - on 6,7%; and application cellular probiotic preparation Bifilak - on 5,4% and 3,3%, respectively. The same tendency was noted during the analysis of indexes of cellular factors of organism protection. Bactericidal activity of blood serum of experimental animals changed both in connection with age, and under influence of probiotic preparations. During all studied periods the bactericidal activity of blood serum was authentically (P less than 0,05) above in experimental groups in comparison with a control group. At 20-days old piglets there was stated the strengthening of bactericidal activity of blood serum. Throughout all period of experiment the superiority of trial animals over control on indicators of lysozyme activity of blood serum was observed

The diseases of newborn calves with a diarrhea syndrome are the most often registered. Application of the prebiotic preparations Biofon and Biofon-AIL to newborn calves daily with colostrum, milk or water in a dose of 20 ml within 20 days, allows to normalize intestinal digestion of an organism of young growth of calves at the expense of activization of microbiocenosis, stimulates metabolism and nonspecific resistance. Use of prebiotics allows to lower disease of young growth at Biofon application on 20%, Biofon-AIL - on 30% and to increase daily average additional weight gain of calves accordingly on 10,4% and 15,9%. Medical and preventive efficiency of application of prebiotic and probiotic preparations at enteritises at calves reaches 80-90%. Prebiotic preparations Biofon and Biofon-AIL make active nonspecific humoral immunity and exchange processes at newborn calves and can successfully be used for preventive maintenance and therapy of diseases of newborn calves with a diarrhea syndrome | У новорожденных телят наиболее часто регистрируются заболевания с диарейным синдромом. Применение пребиотических препаратов Биофон и Биофон АИЛ новорожденным телятам ежедневно с молозивом, молоком или водой в дозе 20 мл в течение 20 дней, позволяет нормализовать кишечное пищеварение организма молодняка за счет активизации микробиоценоза, стимулируют обмен веществ и неспецифическую резистентность. Использование пребиотиков позволяет снизить заболеваемость молодняка при применении биофона -на 20%, биофона-АИЛ - на 30% и увеличить среднесуточные привесы массы телят соответственно на 10,4% и 15,9%. Лечебная и профилактическая эффективность применения пребиотических и пробиотических препаратов при энтеритах у телят достигает 80-90%. Пребиотики Биофон и Биофон АИЛ активизируют неспецифический гуморальный иммунитет и обменные процессы у новорожденных телят и могут успешно использоваться для профилактики и терапии заболеваний новорожденных телят с диарейным синдромом

The modern technology applied on poultry enterprises of the Republic of Belarus made provision for high concentration of poultry population density at the comparatively small housing areas of integrated poultry farms which caused the deterioration of sanitary conditions in poultry houses, especially by the end of the growing period. Broiler chickens grown under such conditions were constantly experiencing the microbe stress which eventually caused the heightened culling and poultry losses caused by different diseases caused both by pathogenic and conditionally pathogenic microflora. For the current disinfection in presence of poultry it was proposed to use sprayings with malic and succinic acids, which made it possible to realize not only the air sanation in poultry houses, but also increase broiler chicken viability. The highest bactericidal activity of apple acid aerosol against air microflora was stated within 3 hours after carrying out indoors treatment. After disinfection the general microbic air contamination decreased in 2-10 times, quantity of microorganisms of colimorphic groups and staphilococcus in 1,4-1,75 and 2-10 times, respectively, in comparison with the original air values realized before air treatment in poultry houses. In the following, there was stated the gradual increase of a level of microbic air contamination within 24 hours. The best effect of the preparation was stated against Staphylococcus. Thus, the quantity of Staphylococcus in air decreased in 10 times in comparison with initial data

There was studied the data on antagonistic activity of a new metabolic probiotic substance derived from the probiotic substance Diamixan. Research of antagonistic activity Diamixan has shown its high activity in the relation of the test-strains of microorganisms: Staphylococcus aureus ATSS 6538, Staphylococcus aureus 209R, Escherichia coli ATSS 71229, Pseudomonas aeruginosa ATSS 9017, Pseudomonas marcescens, Proteus mirabilis ATSS 14153, Bacillus subtilis ATSS 6633, Citrobacter freundii, Candida albicans ATSS 10231, Salmonella enteritidis R1991, Salmonella typhimurium ATSS 24853. In the presence of the preparation, dissolved 1:1, there was a full suppression of growth of all bacteria within 48 hours of cultivation at delution 1:2 and 1:4 the high antagonistic activity of the preparation as the majority of samples remains sterile remained. In the tabular form data on antagonistic activity of the preparation in delution 1:1; 1:2; 1:4 are presented. | Целью работы явилось изучение антагонистической активности метаболитного пробиотика диамиксан. Исследование антагонистической активности диамиксана показало его высокую активность в отношении тест-штаммов микроорганизмов: Staphylococcus aureus АТСС 6538, Staphylococcus aureus 209Р, Escherichia coli ATCC 71229, Pseudomonas aeruginosa ATCC 9017, Pseudomonas marcescens, Proteus mirabilis ATCC 14153, Bacillus subtilis ATCC 6633, Citrobacter freundii, Candida albicans ATCC 10231, Salmonella enteritidis P1991, Salmonella typhimurium ATCC 24853. В присутствии разведённого 1:1 препарата происходило полное подавление роста всех бактерий в течение 48 часов культивирования, при разведении 1:2 и 1:4 сохранялась высокая антагонистическая активность препарата, так как большинство образцов оставалось стерильными. В табличной форме представлены данные по антагонистической активности препарата в разведении 1:1; 1:2; 1:4.

The nonspecific resistance of cows at the interlactation period was studied for the forecasting of the postnatal period progress in the conditions of the Republic of Belarus. Influence of the complex preparations Erimetrinis and Richometrinum on restoration of cow reproductive function was investigated. It was established, that the developed new complex preparation Erimetrinis possessed the uterotonic, antiphlogistic, pathogenetic and stimulating action. Evaluation of the presented preparation was tested have under production conditions and confirmed its high efficiency. After application of Erimetrinis there was noted a fast restoration of both endometrias histostructure, indices of cellular protection, and cow clinical characteristic. Microflora which was discharge from cow uterus content, which were sick with postnatal purulo-catarrhal endometritis, was sensitive and high-sensitivity Erimetrinis and had a zone of growth inhibition from 19,6 up to 36,1 mm, while after Richometrinum application it was sensitive except for staphylococcus and diplococcus in which the growth inhibition zone was from 15,1 up to 15,4 mm. Study of indicators of bactericidal activity of cow blood serum in course of treatment with the Erimetrinis it was established, that starting from the fourth day of the treatment the analysed indicator increased up to 56%, and by the moment of the clinical recovery it was 82,4+/-2,16%. Indicators of lysozymic activity of blood serum at the moment of cow recovery were 13,4+/-1,35 mmol/l. Essential changes were marked in the phagocytic activity of leukocytes, phagocytic numbers and phagocytic index. Cows which were subjected to treatment with Richometrinum all mentioned above indicators were increasing starting from the tenth day of treatment beginning, and clinical recovery was stated on 7,4 days later than after Erimetrinis application

Development of diarrheal diseases of newborn animals has a miltifactorial character and it is very difficult to optimize the structure of microbial population in alimentary tract and to carry out the correction of the microbe status only by means medical preparations. Therefore, for regulation of standard structure of intestine microflora in a complex of medical and preventive measures for diarrhea diseases of young poultry an important role is played by application of probiotics, prebiotics, and immunoamplifiers. In course of study there were used biologically active preparations produced on the basis of ecologically pure products of a natural origin: immunostimulant Alveozan, probiotics Bifidoflorin liquid and Dialakt, and prebiotics Biofon АIL and Biofon. Research was realized on one-day-old broiler chickens of Kobb-500 cross. The obtained data on the positive influence of the studied preparations on microbiocenosis of an alimentary tract of broilers chickens correlated with the indexes of natural resistance (autarcesis).The analyzed preparations made it possible to increase the local protection, stimulation of hematopoiesis (increasing of hematoglobulin, erythrocytes and leukocytes); to increase the blood content of whole protein, albumens and globulins, bactericidal activity of blood serum. Complex introduction of the analysed preparations stimulated the natural disease resistance factors, normalized the metabolic function of poultry, promoted the increasing of chicken livability and productivity

Sodium hypochlorite solution is an effective means in control of noncontagious aetiology diseases, accompanied by development of endogen intoxications. The detoxification action of sodium hypochlorite is that in the body there is no becomes free active oxygen, oxidizing there toxic and ballast substances as bilirubin, urea, ammonia, uric acid, creatinine, cholesterol, carbonic oxide, acetone, acetone acetate, ethanol, methanol, barbiturates, etc. The detoxification action of sodium hypochlorite is shown in neutralization of exotoxins and endotoxins of pathogenic microorganisms as it represents a compound of the small molecular mass and the small structural size. In this connection it freely gets through membranes of cells and oxidizes the toxins containing not only in blood, but also in cells. From this follows, that sodium hypochlorite models not only oxidizing function of cytochrome Р-450 of liver, but also phagocytal function of neutrophilic leucocyte. It leads to inactivation of large toxic molecular compounds both on a surface of uniform elements, and in blood plasma while effective methods reduce intoxication at the expense of removal of the average molecules circulating in plasma

Research on studying of probiotics and prebiotics influence on natural resistance, hemogenesis, metabolism, growth, development and safety are spent on chickens of 1-37-day age in the conditions of clinic of the department of internal noncontagious diseases and the central resarch laboratory of research institute of applied veterinary medicine and biotechnology Vitebsk State Academy of Veterinary Medicine. It was established that the combined use of probiotics and prebiotics increases the defense, raises safety rate and stimulates body weight gain in broiler chickens. Hence, probiotics and prebiotics at joint application render expressed growth-promoting effect, promote high safety of young growth, disease decrease, increase in a weight gain, raise indicators of the general and local protection, stimulate hemogenesis and exchange processes during the most intense periods of bird cultivation. At separate application of probiotics and prebiotics these indicators were a little lower, but authentically above, than at chickens of control group | Исследования по изучению влияния пробиотиков и пребиотиков на естественную резистентность, гемопоэз, обмен веществ, рост, развитие и сохранность, проведены на цыплятах 1-37-дневного возраста в условиях клиники кафедры внутренних незаразных болезней и центральной научно-исследовательской лаборатории Научно-исследовательского института прикладной ветеринарной медицины и биотехнологии УО ВГАВМ. Совместное применение пробиотика и пребиотика усиливает защиту, повышает сохранность и стимулирует прирост массы тела цыплят-бройлеров. Следовательно, про пробиотики и пребиотики при совместном применении оказывают выраженное ростостимулирующее действие, способствуют высокой сохранности молодняка, снижению заболеваемости, увеличению прироста массы, повышают показатели общей и местной защиты, стимулируют гемопоэз и обменные процессы в наиболее напряженные периоды выращивания птицы. При раздельном применении пробиотиков и пребиотиков эти показатели были несколько ниже, но достоверно выше, чем у цыплят контрольной группы

There was studied the nosological profile of calve respiratory diseases and search of a complex way of preventive maintenance of respiratory pathologies with influence both on aetiology, and on the mechanism of disease development. The carried out research have allowed to draw following conclusions: among respiratory diseases at calves till 2-month age prevail diseases of the top respiratory ways (rhinitis, tracheitis, bronchitis); zinc-sulphatic is applied to complex diagnostics of respiratory diseases and predisposition to them of calves with high efficiency of the broncho-pulmonary; carrying out of preventive actions with use of an aerosol from one-chloride iodine and preparation ASD-2 leads to decrease in disease of calves by respiratory diseases and duration of their current; values of the broncho-pulmonary test applied to the control of efficiency of preventive actions, were above in trial groups at application of preparation ASD-2 on 32% and at complex application of preparation ASD-2 and an aerosol of one-chloride iodine on 37%. In the tabular form data on a clinical condition of calves are presented at respiratory diseases and dynamics of the broncho-pulmonary test at calves of trial and control groups. | Целями работы стали изучение нозологического профиля респираторных заболеваний телят и поиск комплексного способа профилактики респираторных патологий с воздействием как на этиологию, так и на механизм развития заболеваний. Проведенные исследования позволили сделать следующие выводы: среди респираторных заболеваний у телят до 2-месячного возраста преобладают заболевания верх¬них дыхательных путей (ринит, трахеит, бронхит); для комплексной диагностики респираторных заболеваний и предрасположенности к ним телят с высокой эффективностью применён цинк-сульфатный бронхолёгочный тест; проведение профилактических мероприятий с использованием аэрозоля из однохлористого йода и препарата АСД-2 приводит к снижению заболеваемости телят респираторными заболеваниями и длительности их течения; значения бронхолёгочного теста, применённого для контроля эффективности профилактических мероприятий, были выше в опытных группах при применении препарата АСД-2 на 32% и при комплексном применении препарата АСД-2 и аэрозоля однохлористого йода на 37%. В табличной форме представлены данные по клиническому состоянию телят при респираторных заболеваниях и динамика БХТ у телят опытных и контрольной групп.