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STAT mRNA kinetics in the central nervous system during autoimmune encephalomyelitis in lewis rats
Jee, Y.H.;Hwang, I.S.;Shin, T.K.;Moon, C.J.;Lim, Y.K.;Yeo, I.K.(Cheju National University, Jeju, Republic of Korea)E-mail:yhjee@cheju.ac.kr | Son, H.Y.(Chungnam National University, Daejeon, Republic of Korea)
To elucidate the molecular mechanisms of autoimmune inflammation in the central nervous system, we examined the expression and localization of STAT1, STAT3, STAT4 and STAT6 molecules during experimental autoimmune encephalomyelitis (EAE) by competitive PCR. In the present study, we quantitated IL-4 and IL-12 p40 mRNA by competitive PCR in the CNS during EAE. IL-4 mRNA was found at early and peak stages. On the other hand, the IL-12 p40 mRNA level reached maximal levels at the peak stage and still found at the recovery stage of the disease.
Show more [+] Less [-]A potential role of Schwann cells in spinal nerve roots in autoimmune central nervous system diseases
Moon, C.J.;Lee, Y.D.;Shin, T.K.(Cheju National University, Jeju, Republic of Korea)E-mail:shint@cheju.ac.kr
The expression of nestin and vimentin in the spinal nerve roots of rats with experimental autoimmune encephalomyelitis (EAE) was studied to ascertain whether Schwann cells in the peripheral nerves respond to acute central nervous system autoimmune injury. Immunohistochemistry demonstrated that nestin was constitutively expressed in the dorsal roots of spinal nerves in control ratsits expression was enhanced in the spinal nerve roots of rats with EAE. Vimentin expression was weak in control rat spinal nerve roots, and it was increased in the dorsal roots of rats with EAE.
Show more [+] Less [-]Pig viral diseases causing reproductive failure in Korea
1992
Kim, B.H. | Kweon, C.H. | An, S.H. | Rhee, J.C. (Rural Development Administration, Anyang (Korea Republic). Veterinary Research Institute)
