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Efficacy of a pseudorabies virus vaccine based on deletion mutant strain 783 that does not express thymidine kinase and glycoprotein I.
1991
Oirschot J.T. van | Moormann R.J.M. | Berns A.J.M. | Gielkens A.L.J.
The vaccine efficacy of a genetically engineered deletion mutant strain of pseudorabies virus, strain 783, was compared with that of the conventionally attenuated Bartha strain. Strain 783 has deletions in the genes coding for glycoprotein I and thymidine kinase. In experiment 1, which had a 3-month interval between vaccination and challenge exposure, strain 783 protected pigs significantly (P < 0.05) better against virulent virus challenge exposure than did the Bartha strain. The growth of pigs vaccinated with strain 783 was not arrested, whereas that of pigs vaccinated with the Bartha strain was arrested for 7 days. Of 8 pigs given strain 783, 4 were fully protected against challenge exposure; none of the pigs given strain Bartha was fully protected. In experiment 2, which had a 3-week interval between vaccination and challenge exposure, the growth of pigs vaccinated with strain 783 was arrested for 3.5 days, whereas that of pigs vaccinated with the Bartha strain was arrested for 6 days. In experiment 3, pigs with moderate titer of maternal antibodies were vaccinated twice IM or once intranasally with either strain 783 or Bartha and were challenge-exposed 3 months after vaccination. Pigs given strain 783 twice IM were significantly (P < 0.05) better protected than were the other pigs. They had growth arrest of only 6 days, compared with 9 days for pigs of other groups, and shed less virus after challenge exposure. Results of this study indicate that the vaccine based on the deletion mutant strain 783 is more efficacious than is the Bartha strain of pseudorabies virus.
Show more [+] Less [-]Antiviral effectiveness of butylated hydroxytoluene against pseudorabies (Aujeszky's disease) virus in cell culture, mice, and swine.
1986
Pirtle E.C. | Sacks J.M. | Nachman R.J.
Second-generation pseudorabies virus vaccine with deletions in thymidine kinase and glycoprotein genes.
1987
Kit S. | Sheppard M. | Ichimura H. | Kit M.
Avidin-biotin complex for immunohistochemical diagnosis of Aujeszky's disease and hog cholera.
1990
Kim S.B. | Sur J.H. | Moon U.G.
Pig viral diseases causing reproductive failure in Korea
1992
Kim, B.H. | Kweon, C.H. | An, S.H. | Rhee, J.C. (Rural Development Administration, Anyang (Korea Republic). Veterinary Research Institute)
Pseudorabies and transmissible gastroenteritis a serological survey in South Africa
1994
Williams, R. (Onderstepoort Veterinary Inst. (South Africa). Virology Section) | Esterhuysen, J.J. | Robinson, J.T.R.
Immunohistochemistry for detection of Aujeszky's disease virus antigens: Protein A-gold labelling of ultrathin sections for electron microscopy
1989
Kim, S.B. (Kyongsang National Univ., Chinju (Korea R.). Coll. of Veterinary Medicine)
The present study was carried out to determine viral antigens and its morphogenesis in the ultrathin frozen and araldite sections of cell cultures infected with ADV by protein A-gold labelling. ADV antigens were labelled with 10nm gold probes, and electron-dense gold particles were mainly present on viral nucleocapsids and viral envelopes. Immunogold labelling in the ultracryosections showed a very low degree of interaction with tissue structures. Immunogold labelling in the ultrathin cryosections can be useful tool for the detection of ADV antigens, and the technique also may provide its great potential for immunocytochemical studies on various virus-host cell interactions
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