Data оn evaluations of therapeutic efficacy of albendazol and fenbendazol agaonst acute and chronic forms of larval cestodiasis of animals were studied in the conditions of the Republic of Belarus by an example of experimentally infested sheep and rabbits. Application of albendazol and fenbendazol both separately and in complex with antioxidant vitamin and mineral additive against the chronic forms of cysticercosis tenuicollis and cysticercosis pisiform was inefficient. But application of albendazol against acute form of cysticercoses caused the lowering of invasion intensity in shepp and rabbits in 3 times, fenbendazol – in 2,6 times. Application of anthelmintic agents in complex with vitamin and mineral composition promoted the lowering of invasion intensity (in 5 and 4,1 times, respectively) and prevented the disease development in 60% of animals.

Data on development of an antigen on the basis of larvae of warble flies grubs (Hypodenna bovis) for diagnostic of spontaneous cattle hypodermosis by means of the indirect fluorescent (IFA) test and with application of blood serum and milk samples realized in the conditions of the Republic of Belarus were presented. Specificity and sensitivity of experimental sample of antigen for revealing of spontaneously infestated with larvae of warble flies with IFA test at hypodermotosis has made about 100%.

It was established that in blood serum of pigs vaccinated against leptospirosis there was an authentic increasing of alanine aminotransferase, alkaline phosphatase and gamma-glutamyltransferase that made proved the presence of residual reactogenicity of biological preparations. In course of the experiment there were used 4 groups of swine which were administrated with 4 types of vaccines: 1. polyvalent vaccine produced in Belarus; 2. experimental thiosulfate vaccine in which there was used 30% sodium solution; 3. experimental emulsified vaccine; experimental emulsified + sodium + thiosulfate vaccine.

In the conditions of the Republic of Belarus there was developed a production technology and there were produced samples of lyophilizated live vaccine against Aujeszky's disease of swine which corresponded to all parameters of control. The vaccine had an expressed phylactic power, induced the development of long-lived immunity of vaccinated piglets.

Comparative effectiveness of application of SV-1 and SV-2 sorbents for preventive treatment of abomazoenterite of 1-2 month old calves was studied in the conditions of the Republic of Belarus. Research results showed that application of SV-1 and SV-2 sorbents rendered a positive influence on hematological and biochemical blood indexes, in particular, there was an increasing of hemoglobin level, albumins content, alkaline reserve, calcium and phosphorous in blood serum. They also rendered the stimulatory effect on natural resistance. The prophylactic effectiveness in experimental group was 100%, in a control one – 60%.

In the conditions of the Republic of Belarus there was made a hepatospecific metabolic profile of cattle blood serum for complex appraisal of liver functional condition. Age-specific peculiarities of biochemical indices including the composition of hepatospecific metabolic profile of cattle blood serum were revealed. On the basis of obtained results there were calculated the appropriate correction coefficients which must be taken into consideration in objective interpretation of laboratory research.

Usage of biological preparation of high antibacterial activity allows to decrease the air pollution by bacteria of colon bacillus group at 25-100%, increase productivity at 17-67 g, safety – at 0,4%, resistance, protein metabolism, protein fractions and some other indices (lysozyme and betalysine activity, leucocytes, erythrocytes, hemoglobin, calcium, phosphorus, iron, magnesium, AST, ALT, urea, cholesterol, bilirubin and glucose)

Application of antiviral preparation Mixoferon for poultry is studied. It is established, that Mixoferon application does not influence negatively on organism of hens, increases intensivity of protein metabolism, including the maintenance of antibodies in blood whey. Mixoferon in dozes of 2,5 ml (500000 МЕ), 1,5 ml (300000 МЕ), 0,5 ml (100000 МЕ) can be used for preventive maintenance and therapy of virus infections of hens

For the well-timed prevention and treatment of sick animals there was analyzed the therapeutic efficiency of a produced survivor serum against acute respiratory diseases of sheep and lambs, as well as Catosal in combination with Nitox 200 against the mixed flow of parainfluenza-3, adenovirus, respiratory syncytial, chiamydial and pasteurellosis infection. Comparative efficiency of all mentioned preparations was presented. Research results showed the correct and timely application of drug preparations as well as their qualitative selection made it possible to lower the death cases. Application of the presented survivor serum in combination with Nitox 200 and Catosal made it possible to lower the loss of cattle in 4-5 times and increase the viability rate of animals

There was studied the therapeutic efficiency of sorbent Lactofiltrum in a complex therapy of abomasoenteritis at calves. It represents the complex preparation containing 75% of hydrolytic lignins and 25% of lactulose. Action of lignins is based on ability to sorb and strongly to keep toxins of exogenous and endogenous origins, the pathogenic microorganisms which are present in enteral mediuim. Lactulose, a part of prebiotics Lactofiltrum, is a synthetic disaccharide. It is not exposed to splitting by enzymes in thin intestines. The active substance lactulose starts to operate in a thick gut where under the influence of intestinal microflora it is transformedto low-molecular organic acids, basically dairy, acetic, oil and propionic. Thanks to acidification of intestinal contents growth of putrefactive and pathogenic microflora chokes, osmotic pressure in a gleam of a thick gut increases. Lactofiltrum possesses high therapeutic efficiency. The experiment has shown 100% effectiveness in treatment. Economic effect is 1,63 rubles in control group and 3,52 rubles in experimental group from 1 ruble of expenditure. This treatment is economically profitable. In the tabular form the content of the general bilirubin, cholesterol, triglycerides and glucose in blood serum, urea and creatinine, daily average body weight gain and epizooty, morphological indicators of blood, dynamics of the general protein and albumens at calves with abomasoenteritis are presented. Lactofiltrum has a high therapeutic effect. Pharmacology action is associated with intestinal digestion normalization due to absorption of toxins and useful bacteria stimulation. The experiment has shown 100% effectiveness in treatment. This treatment is economically profitable.