The dynamics of changes of nonspecific cellular-humoral immunity parameters of sheep in the conditions of in the conditions of oppression of parasympathetic part of autonomic nervous system was studied in the conditions of the Republic of Belarus. For the experimental animals there was applied atropine sulfate. Experiment was realized by an example of two groups (control and experimental) of yeld ewes. Blood was taken from jugular vein before administration of the preparation, and then in 1, 3, 6, 12, 24 hours, 1, 2, 3 days after the beginning of experiment. As a result of realized study there was stated a directly-proportional dependence in changes of phagocytes activity of leukocytes.

Influence of polyphepan with lactulose on dynamics of hematological parameters for the preventive maintenance of gastroenteritis of piglets was studied in the conditions of the Republic of Belarus. Research results showed that application of the presented preparation provided normalization of haemotological parameters of blood, reduction of a level of organism intoxication that was characterized by lowering of concentration lipid peroxidation components.

Development of a production technology of a national anthelminthic preparation Triclafen (from benzimidazole group) on the basis of triclabendazole and fenbendazole was realized in the conditions of the Republic of Belarus. As a result of realized experiments it was found that the developed suspension corresponded the requirements of pharmacopoeial items and can be applied for veterinary practice. Composition of different components with wide action spectrum made it possible to apply it against ruminant animals.

Determination of chronic toxicity of a new selenium-containing preparation Aesel was realized in the conditions of the Republic of Belarus. There was realized endermatic administration of the experimental preparation to laboratory white mice. Studying of sensitivity of some organs and systems of mice and revelation of a degree of reversibility of processes caused by active substances of the drug was realized. The main clinical, pathomorphologic, biochemical, hematological changes in the organism of laboratory animals with induced chronic toxicity were determined.

Application of antiviral preparation Mixoferon for poultry is studied. It is established, that Mixoferon application does not influence negatively on organism of hens, increases intensivity of protein metabolism, including the maintenance of antibodies in blood whey. Mixoferon in dozes of 2,5 ml (500000 МЕ), 1,5 ml (300000 МЕ), 0,5 ml (100000 МЕ) can be used for preventive maintenance and therapy of virus infections of hens

Complex application Alveozan and Dialact conducts to the increase of perservance of birds on 2,1%, daily average additional weight on 3,6%, and also to the decrease in expenses of forages counting on 1 kg of a gain of live weight by 4,1%. Complex influence of Alveozan and Dialact stimulates growth and development lacto- and bifidoflora in a gastroenteric path, reduces quantity of aerobic microorganisms and oppresses a reproduction and settling of a gastroenteric path by bacteria intestinally-paratyphus groups. The economic efficiency of wording out 11,1 rubles on 1 ruble of additional expenses

Application in diets of breeding bull calves of an optimum dose of selenium (0,4 mg on 1 kg of a solid of a diet) renders positive influence on formation of reproductive ability of bull-calves: promotes increase daily average gains live weight on 7,1%, indicators of natural resistance – on 0,6-6,7% and to improvement of quality sperm production – on 16,4% during the winter period. During the summer period daily average gains live weight on 6,8%, indicators of natural resistance – on 0,5-13,9% and to improvement of quality sperm production – on 15,7% accordingly

The given research results of feeding highly productive cows with new forage supplement of humic-melanoidine nature during the milking period show stable mineral metabolism, correction of their redundant supply within the diet, perfection of digestion and transition into milk as well as minimizing consequences of metabolism intensification. Reception new forage supplement promoted improvement of mastering by an animals organism of necessary iron during the given physiological period, to restriction of mastering of the microelements equal to the category of heavy metals

It is determined on the basis of conducted researches on perfection of energy-protein nutrition norm of young cattle of 6-12 months of age that 11,5 MJ of exchange energy at 6-7 months of age and decease to 10 MJ for 12 month of age is needed in 1 kg of dry matter to get 1000 g of average daily weight gain. 8-9 g of digestible, 5 g of non-digestible protein should come for 1 MJ of exchange energy of a diet. 1 kg of DM (Dry Matter) should contain 133-150 g of crude and 46-54 g of non-digestible protein

Efficiency of cultivation of cow preimplantation embryos and support of pluripotent properties in different nutritive media was analyzed; a method of getting early embryos in vitro for the genetically engineered purposes was developed in the conditions of the Republic of Belarus. Oocyte separation was realized in 3; 3-6; 6-9; and 9-12 hours after ovariectomy for the studying of the influence of storage period of ovaries on the output qualitative embryos. Oocyte separation was realized by bisection with adding of 1% of fetal cattle serum, 10 units/ml of gentamicin and 1 unit/ml of heparin. Oocyte-cumulus complexes maturing took place in CO2-bath with 5% of CO2 in atmosphere of maximum humidity and temperature of 38 deg C in TS-199 (Sigma) media with entering of 25 mM/l of buffer Hepes, 10 unit/ml of gentamicin and biologically active substance (20 % of fetal calf serum, 10 mg/ml of bovine serum albumin and 5 % of estrous cow serum with 10 mg/ml of bovine serum albumin). Research result showed that application of 10 mg/ml of bovine serum albumin into TS-199 media made it possible to increase the yield of cattle embryos at the preimplantation stages in vitro conditions on 19,1%, as well as to increase the fetal calf serum in quantity 15% to the nutritive media volume up to 16,0 %. Application of sodium pyruvate and calcium lactate in the process of cultivation of early cattle embryos obtained in vitro conditions made it possible to increase the yield of preimplantation embryos on 5,4 %. Specifically, the level of transformation of morulas into blastocysts was 44,4 %