The therapeutic efficacy of two formulations, one containing garlic and other lead carbonate and acetate, camphor, neem and eucalyptus oils were assessed in 18 and 29 clinical cases of dermatological disorders in dogs, respectively. None of the preparation showed satisfactory results against mange infestation. Both the preparations were almost equally effective in cases of fungal and non-specific dermatitis.

The study was conducted to determine the role of Ca2+ and K+ channels in Moringa oleifera flowers extract-induced myometrial contractility of buffalo uterus. Myometrial strips were prepared, mounted in an organ bath containing Ringer Locke solution maintained at 37oC and responses recorded using a kymograph. Moringa oleifera flowers extract (MOFE) produced quite conspicuous and concentration-dependent contractile effect on buffalo myometrium and the EC50 value was found to be 31.62 ìg/ml. Verapamil (10-12M) not only completely inhibited normal spontaneous rhythmic contractions of myometrial uterine strips but also inhibited MOFE-induced spontaneous rhythmic contractions. Ethylene glycol tetra acetic acid (EGTA; 0.1-0.2mM) reduced both the frequency and amplitude of spontaneous contractions and also produced around 28% reduction in the amplitude of MOFE-induced contractile effect. Similalrly, pinacidil (10-6M-10-5M), glibenclamide (10-5M) and 4- amino pyridine (4-AP; 1mM) pretreatments inhibited spontaneous contractions as well as the contractile effects of MOFE (250ìg/ml). Based on the results of present study, it may be inferred that both the extra- and intracellular Ca2+ are very vital for the oxytocic effect of MOFE. Functional presence of K+ ATP, K+ V and/or K+ Ca channels in buffalo myometrium and their involvement in mediating MOFEinduced contractility can not be ruled out. Moringa oleifera flowers possessed promising oxytocic activity and can be exploited in drug-development programme for evolving natural and effective oxytocic or abortifacient.